R J Buka1, R J Crossman2, C L Melchior1, A P Huissoon1,3, S Hackett4, S Dorrian5, M W Cooke2,5, M T Krishna1,2,6. 1. Department of Allergy and Immunology, Heart of England NHS Foundation Trust, Birmingham, UK. 2. Warwick Medical School, University of Warwick, Warwick, UK. 3. School of Immunity and Infection, University of Birmingham, Birmingham, UK. 4. Department of Paediatric Infectious Diseases and Immunology, Heart of England NHS Foundation Trust, Birmingham, UK. 5. Department of Emergency Medicine, Heart of England NHS Foundation Trust, Birmingham, UK. 6. School of Life & Health Sciences, Aston Medical School, Aston University, Birmingham, UK.
Abstract
BACKGROUND: The incidence of anaphylaxis in South Asians (Indian, Pakistani and Bangladeshi ethnicity) is unknown. Birmingham is a British city with a disproportionately large population of South Asians (22.5%) compared with the rest of the UK (4.9%). The main aims of this study were to determine the incidence and severity of anaphylaxis in this population and to investigate the differences between the South Asian and White populations. METHODS: A retrospective electronic search of emergency department attendances at three hospitals in Birmingham during 2012 was carried out. Wide search terms were used, medical notes were scrutinized, and the World Allergy Organization diagnostic criteria for anaphylaxis were applied. Patients' age, sex, ethnicity and home postal code were collected, reactions were graded by severity, and other relevant details including specialist assessment were extracted. Multivariate analysis was undertaken using 2011 UK census data. RESULTS: Age-, sex- and ethnicity-standardized incidence rate of anaphylaxis was 34.5 per 100 000 person-years. Multivariate logistic regression which controlled for the confounders of age, sex and level of socioeconomic deprivation showed that incidence was higher in the South Asian population (OR 1.48, P = 0.005). Incidence rate in the South Asian population was 58.3 cases per 100 000 person-years compared to 31.5 in the White population. South Asian children were more likely to present with severe anaphylaxis (OR 5.31, P = 0.002). CONCLUSIONS: Incidence of anaphylaxis is significantly higher in British South Asians compared to the white population. British South Asian children are at a greater risk of severe anaphylaxis than White children.
BACKGROUND: The incidence of anaphylaxis in South Asians (Indian, Pakistani and Bangladeshi ethnicity) is unknown. Birmingham is a British city with a disproportionately large population of South Asians (22.5%) compared with the rest of the UK (4.9%). The main aims of this study were to determine the incidence and severity of anaphylaxis in this population and to investigate the differences between the South Asian and White populations. METHODS: A retrospective electronic search of emergency department attendances at three hospitals in Birmingham during 2012 was carried out. Wide search terms were used, medical notes were scrutinized, and the World Allergy Organization diagnostic criteria for anaphylaxis were applied. Patients' age, sex, ethnicity and home postal code were collected, reactions were graded by severity, and other relevant details including specialist assessment were extracted. Multivariate analysis was undertaken using 2011 UK census data. RESULTS: Age-, sex- and ethnicity-standardized incidence rate of anaphylaxis was 34.5 per 100 000 person-years. Multivariate logistic regression which controlled for the confounders of age, sex and level of socioeconomic deprivation showed that incidence was higher in the South Asian population (OR 1.48, P = 0.005). Incidence rate in the South Asian population was 58.3 cases per 100 000 person-years compared to 31.5 in the White population. South Asian children were more likely to present with severe anaphylaxis (OR 5.31, P = 0.002). CONCLUSIONS: Incidence of anaphylaxis is significantly higher in British South Asians compared to the white population. British South Asian children are at a greater risk of severe anaphylaxis than White children.
Authors: Luciana Kase Tanno; Ana Luiza Bierrenbach; F Estelle R Simons; Victoria Cardona; Bernard Yu-Hor Thong; Nicolas Molinari; Moises A Calderon; Margitta Worm; Yoon-Seok Chang; Nikolaos G Papadopoulos; Thomas Casale; Pascal Demoly Journal: Allergy Asthma Clin Immunol Date: 2018-04-04 Impact factor: 3.406
Authors: Christina J Jones; Priyamvada Paudyal; Robert M West; Adel H Mansur; Nicola Jay; Nick Makwana; Sarah Baker; Mamidipudi T Krishna Journal: Clin Exp Allergy Date: 2022-04-14 Impact factor: 5.401
Authors: Paul J Turner; Elizabeth Andoh-Kesson; Sarah Baker; Alexa Baracaia; Alisha Barfield; Julie Barnett; Karen Brunas; Chun-Han Chan; Stella Cochrane; Katherine Cowan; Mary Feeney; Simon Flanagan; Adam T Fox; Leigh George; M Hazel Gowland; Christina Heeley; Ian Kimber; Rebecca Knibb; Kirsty Langford; Alan Mackie; Tim McLachlan; Lynne Regent; Matthew Ridd; Graham Roberts; Adrian Rogers; Guy Scadding; Sarah Stoneham; Darryl Thomson; Heidi Urwin; Carina Venter; Michael Walker; Rachel Ward; Ross A R Yarham; Maggie Young; John O'Brien Journal: Clin Exp Allergy Date: 2021-07-23 Impact factor: 5.401