Ute Oltmanns1, Karin Palmowski2, Mark Wielpütz3, Nicolas Kahn2, Eva Baroke4, Ralf Eberhardt2, Sabine Wege2, Matthias Wiebel2, Michael Kreuter2, Felix J F Herth2, Marcus A Mall5. 1. Department of Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Centre Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Department of Translational Pulmonology, University Hospital Heidelberg, Heidelberg, Germany. 2. Department of Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Centre Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany. 3. Translational Lung Research Centre Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Diagnostic and Interventional Radiology, University Hospital, Heidelberg, Germany; Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik, University Hospital, Heidelberg, Germany. 4. Department of Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University Hospital Heidelberg, Heidelberg, Germany. 5. Translational Lung Research Centre Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Department of Translational Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.
Abstract
BACKGROUND: Chronic inflammation and remodeling of the airways remain a hallmark of cystic fibrosis (CF). However, knowledge of the associated mucosal micro-anatomical changes is limited. We evaluated the potential of optical coherence tomography (OCT) for in vivo imaging of the upper airway mucosa in CF patients. METHODS: A flexible OCT probe was used for cross-sectional imaging of the nasal mucosa in 25 CF patients and 25 healthy controls. RESULTS: OCT images showed mucosal details including epithelium, basement membrane, lamina propria with seromucinous glands, and underlying cartilaginous structures. Mean nasal mucosa and epithelial layer thickness were increased in CF compared to controls. In CF patients, antibiotic therapy was associated with reduced nasal mucosa thickening. CONCLUSIONS: OCT detected mucosal changes associated with upper airway inflammation and response to antibiotic therapy in CF patients. OCT may be a useful tool for quantitative in vivo assessment of structural changes of the airway mucosa.
BACKGROUND: Chronic inflammation and remodeling of the airways remain a hallmark of cystic fibrosis (CF). However, knowledge of the associated mucosal micro-anatomical changes is limited. We evaluated the potential of optical coherence tomography (OCT) for in vivo imaging of the upper airway mucosa in CFpatients. METHODS: A flexible OCT probe was used for cross-sectional imaging of the nasal mucosa in 25 CFpatients and 25 healthy controls. RESULTS: OCT images showed mucosal details including epithelium, basement membrane, lamina propria with seromucinous glands, and underlying cartilaginous structures. Mean nasal mucosa and epithelial layer thickness were increased in CF compared to controls. In CFpatients, antibiotic therapy was associated with reduced nasal mucosa thickening. CONCLUSIONS: OCT detected mucosal changes associated with upper airway inflammation and response to antibiotic therapy in CFpatients. OCT may be a useful tool for quantitative in vivo assessment of structural changes of the airway mucosa.
Authors: Attila Óvári; N Starke; T Schuldt; S Schröder; S Zonnur; A Erbersdobler; E Lankenau; O Stachs; T Just; R Mlynski; B Olzowy Journal: Eur Arch Otorhinolaryngol Date: 2018-05-08 Impact factor: 2.503
Authors: Hui Min Leung; Susan E Birket; Chulho Hyun; Timothy N Ford; Dongyao Cui; George M Solomon; Ren-Jay Shei; Adegboyega Timothy Adewale; Andrew R Lenzie; Courtney M Fernandez-Petty; Hui Zheng; Justin H Palermo; Do-Yeon Cho; Bradford A Woodworth; Lael M Yonker; Bryan P Hurley; Steven M Rowe; Guillermo J Tearney Journal: Sci Transl Med Date: 2019-08-07 Impact factor: 17.956
Authors: Hinnerk Schulz-Hildebrandt; Mario Pieper; Charlotte Stehmar; Martin Ahrens; Christian Idel; Barbara Wollenberg; Peter König; Gereon Hüttmann Journal: Biomed Opt Express Date: 2018-01-16 Impact factor: 3.732