Majuran Perinpam1, Erin B Ware2, Jennifer A Smith3, Stephen T Turner1, Sharon L R Kardia3, John C Lieske4. 1. Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN. 2. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI; Institute for Social Research, University of Michigan, Ann Arbor, MI. 3. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI. 4. Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Electronic address: Lieske.John@mayo.edu.
Abstract
OBJECTIVE: To investigate the effect of demographics including age and sex on excretion of 4 key urinary factors (calcium [Ca], magnesium [Mg], oxalate and uric acid [UA]) related to kidney stone risk. METHODS: Twenty-four-hour urine samples were collected from non-Hispanic white sibships in Rochester, MN. Height, weight, blood pressure, serum creatinine, and cystatin C were measured. Diet was assessed using the Viocare food frequency questionnaire. Effects of demographics and dietary elements on urinary excretions were evaluated in univariate, multivariate, and interaction models that included age, sex, and body mass index (BMI). RESULTS: Samples were available from 709 individuals. In multivariate models, sex was a significant predictor of all 4 urinary factors, age was significant for all but UA excretion, and serum creatinine was significant only for Ca and Mg excretion (P <.05). BMI or weight positively correlated with Mg, oxalate, and UA excretion (P <.05). Use of a thiazide diuretic (lower) and dietary protein (higher) were associated with Ca excretion, whereas dietary Ca was associated with higher Mg excretion. Urinary UA excretion increased with animal protein intake and cystatin C estimated glomerular filtration rate (eGFR) and was lower with concurrent loop diuretic use. Significant interaction effects on urinary UA excretion were observed for loop diuretic use and sex, eGFR and sex, age and animal protein intake, and BMI and eGFR (P <.05). CONCLUSION: Age and sex influence excretion of key urinary factors related to kidney stone risk and should be taken into account when evaluating kidney stone patients.
OBJECTIVE: To investigate the effect of demographics including age and sex on excretion of 4 key urinary factors (calcium [Ca], magnesium [Mg], oxalate and uric acid [UA]) related to kidney stone risk. METHODS: Twenty-four-hour urine samples were collected from non-Hispanic white sibships in Rochester, MN. Height, weight, blood pressure, serum creatinine, and cystatin C were measured. Diet was assessed using the Viocare food frequency questionnaire. Effects of demographics and dietary elements on urinary excretions were evaluated in univariate, multivariate, and interaction models that included age, sex, and body mass index (BMI). RESULTS: Samples were available from 709 individuals. In multivariate models, sex was a significant predictor of all 4 urinary factors, age was significant for all but UA excretion, and serum creatinine was significant only for Ca and Mg excretion (P <.05). BMI or weight positively correlated with Mg, oxalate, and UA excretion (P <.05). Use of a thiazide diuretic (lower) and dietary protein (higher) were associated with Ca excretion, whereas dietary Ca was associated with higher Mg excretion. Urinary UA excretion increased with animal protein intake and cystatin C estimated glomerular filtration rate (eGFR) and was lower with concurrent loop diuretic use. Significant interaction effects on urinary UA excretion were observed for loop diuretic use and sex, eGFR and sex, age and animal protein intake, and BMI and eGFR (P <.05). CONCLUSION: Age and sex influence excretion of key urinary factors related to kidney stone risk and should be taken into account when evaluating kidney stonepatients.
Authors: Margaret S Pearle; David S Goldfarb; Dean G Assimos; Gary Curhan; Cynthia J Denu-Ciocca; Brian R Matlaga; Manoj Monga; Kristina L Penniston; Glenn M Preminger; Thomas M T Turk; James R White Journal: J Urol Date: 2014-05-20 Impact factor: 7.450
Authors: Lesley A Inker; Christopher H Schmid; Hocine Tighiouart; John H Eckfeldt; Harold I Feldman; Tom Greene; John W Kusek; Jane Manzi; Frederick Van Lente; Yaping Lucy Zhang; Josef Coresh; Andrew S Levey Journal: N Engl J Med Date: 2012-07-05 Impact factor: 91.245
Authors: Alan R Kristal; Ann S Kolar; James L Fisher; Jesse J Plascak; Phyllis J Stumbo; Rick Weiss; Electra D Paskett Journal: J Acad Nutr Diet Date: 2014-01-24 Impact factor: 4.910
Authors: Justin I Friedlander; Daniel M Moreira; Christopher Hartman; Sammy E Elsamra; Arthur D Smith; Zeph Okeke Journal: J Endourol Date: 2014-03-25 Impact factor: 2.942
Authors: Andrew S Levey; Lesley A Stevens; Christopher H Schmid; Yaping Lucy Zhang; Alejandro F Castro; Harold I Feldman; John W Kusek; Paul Eggers; Frederick Van Lente; Tom Greene; Josef Coresh Journal: Ann Intern Med Date: 2009-05-05 Impact factor: 25.391
Authors: Matthias B Moor; Nasser A Dhayat; Simeon Schietzel; Michael Grössl; Bruno Vogt; Daniel G Fuster Journal: Urolithiasis Date: 2022-02-24 Impact factor: 2.861
Authors: Erin B Ware; Jennifer A Smith; Wei Zhao; Ron T Ganesvoort; Gary C Curhan; Martin Pollak; David B Mount; Stephen T Turner; Guotao Chen; Ronak Jagdeep Shah; Sharon L R Kardia; John C Lieske Journal: Mayo Clin Proc Innov Qual Outcomes Date: 2019-11-22