Literature DB >> 26203778

Activatable and Cell-Penetrable Multiplex FRET Nanosensor for Profiling MT1-MMP Activity in Single Cancer Cells.

Eddie Y Chung, Christopher J Ochs1, Yi Wang2, Lei Lei2, Qin Qin, Andrew M Smith2, Alex Y Strongin3, Roger Kamm1, Ying-Xin Qi4, Shaoying Lu2, Yingxiao Wang2.   

Abstract

We developed a quantum-dot-based fluorescence resonance energy transfer (QD-FRET) nanosensor to visualize the activity of matrix metalloproteinase (MT1-MMP) at cell membrane. A bended peptide with multiple motifs was engineered to position the FRET pair at a close proximity to allow energy transfer, which can be cleaved by active MT1-MMP to result in FRET changes and the exposure of cell penetrating sequence. Via FRET and penetrated QD signals, the nanosensor can profile cancer cells.

Entities:  

Keywords:  FRET nanosensor; MT1-MMP; activatable cell-penetrating peptide; cancer; multiplex signals; single cell

Mesh：

Substances：

Year:  2015        PMID： 26203778      PMCID： PMC4675668          DOI： 10.1021/acs.nanolett.5b01047

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  47 in total

1.  Visualizing the mechanical activation of Src.

Authors:  Yingxiao Wang; Elliot L Botvinick; Yihua Zhao; Michael W Berns; Shunichi Usami; Roger Y Tsien; Shu Chien
Journal:  Nature       Date:  2005-04-21       Impact factor: 49.962

Review 2.  MT1-MMP: a potent modifier of pericellular microenvironment.

Authors:  Yoshifumi Itoh; Motoharu Seiki
Journal:  J Cell Physiol       Date:  2006-01       Impact factor: 6.384

3.  Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates.

Authors:  Igor L Medintz; Aaron R Clapp; Florence M Brunel; Theresa Tiefenbrunn; H Tetsuo Uyeda; Eddie L Chang; Jeffrey R Deschamps; Philip E Dawson; Hedi Mattoussi
Journal:  Nat Mater       Date:  2006-06-25       Impact factor: 43.841

Review 4.  Bioconjugated quantum dots for in vivo molecular and cellular imaging.

Authors:  Andrew M Smith; Hongwei Duan; Aaron M Mohs; Shuming Nie
Journal:  Adv Drug Deliv Rev       Date:  2008-04-10       Impact factor: 15.470

5.  Protease-modulated cellular uptake of quantum dots.

Authors:  Yan Zhang; Min Kyung So; Jianghong Rao
Journal:  Nano Lett       Date:  2006-09       Impact factor: 11.189

6.  A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases.

Authors:  Steven J Kridel; Hisako Sawai; Boris I Ratnikov; Emily I Chen; Weizhong Li; Adam Godzik; Alex Y Strongin; Jeffrey W Smith
Journal:  J Biol Chem       Date:  2002-04-16       Impact factor: 5.157

Review 7.  The other side of MMPs: protective roles in tumor progression.

Authors:  Michelle D Martin; Lynn M Matrisian
Journal:  Cancer Metastasis Rev       Date:  2007-12       Impact factor: 9.264

8.  Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion.

Authors:  Yali Zhai; Kevin B Hotary; Bin Nan; F Xavier Bosch; Nubia Muñoz; Stephen J Weiss; Kathleen R Cho
Journal:  Cancer Res       Date:  2005-08-01       Impact factor: 12.701

9.  The inactive 44-kDa processed form of membrane type 1 matrix metalloproteinase (MT1-MMP) enhances proteolytic activity via regulation of endocytosis of active MT1-MMP.

Authors:  Jin-Ah Cho; Pamela Osenkowski; Huiren Zhao; Seaho Kim; Marta Toth; Kristina Cole; Amro Aboukameel; Allen Saliganan; Lucia Schuger; R Daniel Bonfil; Rafael Fridman
Journal:  J Biol Chem       Date:  2008-04-15       Impact factor: 5.157

10.  Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.

Authors:  Vladislav S Golubkov; Alexei V Chekanov; Sergey A Shiryaev; Alexander E Aleshin; Boris I Ratnikov; Katarzyna Gawlik; Ilian Radichev; Khatereh Motamedchaboki; Jeffrey W Smith; Alex Y Strongin
Journal:  J Biol Chem       Date:  2007-10-15       Impact factor: 5.157
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  9 in total

Review 1.  Quantum Dot-Dye Conjugates for Biosensing, Imaging, and Therapy.

Authors:  Sungwook Jung; Xiaoyuan Chen
Journal:  Adv Healthc Mater       Date:  2018-06-03       Impact factor: 9.933

2.  Preparation and Characterization of Quantum Dot-Peptide Conjugates Based on Polyhistidine Tags.

Authors:  Katherine D Krause; Hsin-Yun Tsai; Kelly Rees; Hyungki Kim; W Russ Algar
Journal:  Methods Mol Biol       Date:  2021

3.  A cell surface display fluorescent biosensor for measuring MMP14 activity in real-time.

Authors:  Alexander Braun; Matthew J Farber; Zachary A Klase; Peter B Berget; Kenneth A Myers
Journal:  Sci Rep       Date:  2018-04-12       Impact factor: 4.379

4.  Intermolecular distance measurement with TNT suppressor on the M13 bacteriophage-based Förster resonance energy transfer system.

Authors:  Inhong Kim; Hyerin Song; Chuntae Kim; Minwoo Kim; Kwangseuk Kyhm; Kyujung Kim; Jin-Woo Oh
Journal:  Sci Rep       Date:  2019-01-24       Impact factor: 4.379

Review 5.  Monitoring Proteolytic Activity in Real Time: A New World of Opportunities for Biosensors.

Authors:  Rui Oliveira-Silva; Mariana Sousa-Jerónimo; David Botequim; Nuno J O Silva; Pedro M R Paulo; Duarte M F Prazeres
Journal:  Trends Biochem Sci       Date:  2020-05-05       Impact factor: 13.807

Review 6.  Different Approaches to Develop Nanosensors for Diagnosis of Diseases.

Authors:  Nina Arndt; Huong D N Tran; Run Zhang; Zhi Ping Xu; Hang T Ta
Journal:  Adv Sci (Weinh)       Date:  2020-10-28       Impact factor: 16.806

7.  MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging.

Authors:  Xiuru Ji; Shuping Xie; Yan Jiao; Xiaojuan Zhang; Duxin Sun; Victor C Yang; Mei Wang; Huining He; Lu Sun
Journal:  Biomater Sci       Date:  2020-03-18       Impact factor: 6.843

8.  LncRNA GAS5 is a critical regulator of metastasis phenotype of melanoma cells and inhibits tumor growth in vivo.

Authors:  Long Chen; Huixin Yang; Yanbin Xiao; Xiaoxia Tang; Yuqian Li; Qiaoqiao Han; Junping Fu; Yuye Yang; Yuechun Zhu
Journal:  Onco Targets Ther       Date:  2016-07-04       Impact factor: 4.147

Review 9.  Application of FRET Biosensors in Mechanobiology and Mechanopharmacological Screening.

Authors:  Longwei Liu; Fangchao He; Yiyan Yu; Yingxiao Wang
Journal:  Front Bioeng Biotechnol       Date:  2020-11-09
  9 in total

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