| Literature DB >> 26203668 |
Motoyuki Isoda1, Kazuyuki Sato1, Masato Funakoshi1, Keiko Omura1, Atsushi Tarui1, Masaaki Omote1, Akira Ando1.
Abstract
The combination of Et2Zn and RhCl(PPh3)3 led to the facile generation of a rhodium-hydride complex (Rh-H) that catalyzed the 1,4-reduction of α,β-unsaturated esters. The resulting rhodium enolate performed as a Reformatsky-type reagent and reacted with various imines to give syn-β-lactams in good to excellent yields with high diastereoselectivity.Entities:
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Year: 2015 PMID： 26203668 DOI： 10.1021/acs.joc.5b01233
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354