Woo Jin Lee1, Hyun Seok Choi1, Jinhee Jang2, Jinkyeong Sung1, Tae-Won Kim3, Jaseong Koo3, Yong Sam Shin4, So-Lyung Jung1, Kook-Jin Ahn1, Bum-Soo Kim1. 1. Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, South Korea. 2. Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 137-701, South Korea. znee@catholic.ac.kr. 3. Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, South Korea. 4. Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Abstract
INTRODUCTION: The aim of this study is to evaluate the degree of atherosclerotic changes in intracranial arteries by assessing arterial wall thickness using T1-weighted 3D-turbo spin echo (3D-TSE) and time-of-flight MR angiography (TOF-MRA) in patients with acute ischemic stroke as compared with unaffected controls. METHODS: Thirty-three patients with acute ischemic stroke and 36 control patients were analyzed. Acute ischemic stroke patients were divided according to TOAST classification. At both distal internal carotid arteries and basilar artery without stenosis, TOF-MRA was used to select non-stenotic portion of assessed arteries. 3D-TSE was used to measure the area including the lumen and wall (AreaOuter) and luminal area (AreaInner). The area of the vessel wall (AreaVW) of assessed intracranial arteries and the ratio index (RI) of each patient were determined. RESULTS: AreaInner, AreaOuter, AreaVW, and RI showed good inter-observer reliability and excellent intra-observer reliability. AreaInner did not significantly differ between stroke patients and controls (P = 0.619). However, AreaOuter, AreaVW, and RI were significantly larger in stroke patients (P < 0.001). The correlation coefficient between AreaInner and AreaOuter was higher in the controls (r = 0.918) than in large vessel disease patients (r = 0.778). RI of large vessel disease patients was significantly higher than that of normal control, small vessel disease, and cardioembolic groups. CONCLUSION: In patients with acute ischemic stroke, wall thickening and positive remodeling are evident in non-stenotic intracranial arteries. This change is more definite in stroke subtype that is related to atherosclerosis than that in other subtypes which are not.
INTRODUCTION: The aim of this study is to evaluate the degree of atherosclerotic changes in intracranial arteries by assessing arterial wall thickness using T1-weighted 3D-turbo spin echo (3D-TSE) and time-of-flight MR angiography (TOF-MRA) in patients with acute ischemic stroke as compared with unaffected controls. METHODS: Thirty-three patients with acute ischemic stroke and 36 control patients were analyzed. Acute ischemic strokepatients were divided according to TOAST classification. At both distal internal carotid arteries and basilar artery without stenosis, TOF-MRA was used to select non-stenotic portion of assessed arteries. 3D-TSE was used to measure the area including the lumen and wall (AreaOuter) and luminal area (AreaInner). The area of the vessel wall (AreaVW) of assessed intracranial arteries and the ratio index (RI) of each patient were determined. RESULTS: AreaInner, AreaOuter, AreaVW, and RI showed good inter-observer reliability and excellent intra-observer reliability. AreaInner did not significantly differ between strokepatients and controls (P = 0.619). However, AreaOuter, AreaVW, and RI were significantly larger in strokepatients (P < 0.001). The correlation coefficient between AreaInner and AreaOuter was higher in the controls (r = 0.918) than in large vessel diseasepatients (r = 0.778). RI of large vessel diseasepatients was significantly higher than that of normal control, small vessel disease, and cardioembolic groups. CONCLUSION: In patients with acute ischemic stroke, wall thickening and positive remodeling are evident in non-stenotic intracranial arteries. This change is more definite in stroke subtype that is related to atherosclerosis than that in other subtypes which are not.
Authors: Anja G van der Kolk; Jaco J M Zwanenburg; Manon Brundel; Geert-Jan Biessels; Fredy Visser; Peter R Luijten; Jeroen Hendrikse Journal: Stroke Date: 2011-07-14 Impact factor: 7.914
Authors: R H Swartz; S S Bhuta; R I Farb; R Agid; R A Willinsky; K G Terbrugge; J Butany; B A Wasserman; D M Johnstone; F L Silver; D J Mikulis Journal: Neurology Date: 2009-02-17 Impact factor: 9.910
Authors: Young Seo Kim; Sung-Hwan Lim; Ki-Wook Oh; Ji Young Kim; Seong-Ho Koh; Juhan Kim; Sung Hyuk Heo; Dae-Il Chang; Young-Jun Lee; Hyun Young Kim Journal: Atherosclerosis Date: 2012-08-13 Impact factor: 5.162
Authors: Ye Qiao; Steven R Zeiler; Saeedeh Mirbagheri; Richard Leigh; Victor Urrutia; Robert Wityk; Bruce A Wasserman Journal: Radiology Date: 2014-01-16 Impact factor: 11.105
Authors: Mikael Mazighi; Julien Labreuche; Fernando Gongora-Rivera; Charles Duyckaerts; Jean-Jacques Hauw; Pierre Amarenco Journal: Stroke Date: 2008-02-28 Impact factor: 7.914
Authors: Ji Eun Park; Seung Chai Jung; Sang Hun Lee; Ji Young Jeon; Ji Ye Lee; Ho Sung Kim; Choong-Gon Choi; Sang Joon Kim; Deok Hee Lee; Seon-Ok Kim; Sun U Kwon; Dong-Wha Kang; Jong S Kim Journal: Eur Radiol Date: 2017-05-12 Impact factor: 5.315