| Literature DB >> 26198393 |
Elad Ziv1, Eric Dean2, Donglei Hu1, Alessandro Martino3, Daniel Serie4, Karen Curtin5, Daniele Campa3, Blake Aftab6, Paige Bracci7, Gabriele Buda8, Yi Zhao5, Jennifer Caswell-Jin1, Robert Diasio9, Charles Dumontet10, Marek Dudziński11, Laura Fejerman1, Alexandra Greenberg12, Scott Huntsman1, Krzysztof Jamroziak13, Artur Jurczyszyn14, Shaji Kumar15, Djordje Atanackovic5, Martha Glenn5, Lisa A Cannon-Albright5, Brandt Jones5, Adam Lee9, Herlander Marques16, Thomas Martin6, Joaquin Martinez-Lopez17, Vincent Rajkumar15, Juan Sainz18, Annette Juul Vangsted19, Marzena Wątek20, Jeffrey Wolf6, Susan Slager21, Nicola J Camp5, Federico Canzian3, Celine Vachon22.
Abstract
Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the association in the IMMEnSE cohort including 772 patients, and a University of Utah cohort including 318 patients (rs72773978 P=0.044). Using publicly available data, we find that the minor allele was associated with increased expression of FOPNL and increased expression of FOPNL was associated with higher expression of centrosomal genes and with shorter survival. Polymorphisms at the FOPNL locus are associated with survival among MM patients.Entities:
Mesh：
Year: 2015 PMID： 26198393 PMCID： PMC4656791 DOI： 10.1038/ncomms8539
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919