PURPOSE OF REVIEW: Because of the relatively small numbers of pediatric patients with congenital heart disease cared for in any individual center, there is a significant need for multicenter clinical studies to validate new medical or surgical therapies. The Pediatric Heart Network (PHN), with 15 years of experience in multicenter clinical research, has tackled numerous challenges when conducting multicenter studies. RECENT FINDINGS: This review describes the challenges encountered and the strategies employed to conduct high-quality, collaborative research in pediatric cardiovascular disease. SUMMARY: Sharing lessons learned from the PHN can provide guidance to investigators interested in conducting pediatric multicenter studies.
PURPOSE OF REVIEW: Because of the relatively small numbers of pediatric patients with congenital heart disease cared for in any individual center, there is a significant need for multicenter clinical studies to validate new medical or surgical therapies. The Pediatric Heart Network (PHN), with 15 years of experience in multicenter clinical research, has tackled numerous challenges when conducting multicenter studies. RECENT FINDINGS: This review describes the challenges encountered and the strategies employed to conduct high-quality, collaborative research in pediatric cardiovascular disease. SUMMARY: Sharing lessons learned from the PHN can provide guidance to investigators interested in conducting pediatric multicenter studies.
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Authors: L Mahony; L A Sleeper; P A W Anderson; W M Gersony; B W McCrindle; L L Minich; J W Newburger; J P Saul; V L Vetter; G D Pearson Journal: Pediatr Cardiol Date: 2006 Mar-Apr Impact factor: 1.655
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