Kiran Maski1, Hannah Holbrook2, Dara Manoach3, Ellen Hanson4, Kush Kapur5, Robert Stickgold6,7. 1. Department of Neurology, Boston Children's Hospital, Boston, MA. 2. Department of Psychology, University of Vermont, Burlington, VT. 3. Department of Psychiatry, Massachusetts General Hospital, Boston, MA. 4. Department of Medicine, Boston Children's Hospital, Boston, MA. 5. Center for Health Statistics, Boston Children's Hospital, Boston, MA. 6. Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA. 7. Department of Psychiatry, Harvard Medical School, Boston, MA.
Abstract
STUDY OBJECTIVES: Examine the role of sleep in the consolidation of declarative memory in children with autism spectrum disorder (ASD). DESIGN: Case-control study. SETTING: Home-based study with sleep and wake conditions. PARTICIPANTS: Twenty-two participants with ASD and 20 control participants between 9 and 16 y of age. MEASUREMENTS AND RESULTS: Participants were trained to criterion on a spatial declarative memory task and then given a cued recall test. Retest occurred after a period of daytime wake (Wake) or a night of sleep (Sleep) with home-based polysomnography; Wake and Sleep conditions were counterbalanced. Children with ASD had poorer sleep efficiency than controls, but other sleep macroarchitectural and microarchitectural measures were comparable after controlling for age and medication use. Both groups demonstrated better memory consolidation across Sleep than Wake, although participants with ASD had poorer overall memory consolidation than controls. There was no interaction between group and condition. The change in performance across sleep, independent of medication and age, showed no significant relationships with any specific sleep parameters other than total sleep time and showed a trend toward less forgetting in the control group. CONCLUSION: This study shows that despite their more disturbed sleep quality, children with autism spectrum disorder (ASD) still demonstrate more stable memory consolidation across sleep than in wake conditions. The findings support the importance of sleep for stabilizing memory in children with and without neurodevelopmental disabilities. Our results suggest that improving sleep quality in children with ASD could have direct benefits to improving their overall cognitive functioning.
STUDY OBJECTIVES: Examine the role of sleep in the consolidation of declarative memory in children with autism spectrum disorder (ASD). DESIGN: Case-control study. SETTING: Home-based study with sleep and wake conditions. PARTICIPANTS: Twenty-two participants with ASD and 20 control participants between 9 and 16 y of age. MEASUREMENTS AND RESULTS:Participants were trained to criterion on a spatial declarative memory task and then given a cued recall test. Retest occurred after a period of daytime wake (Wake) or a night of sleep (Sleep) with home-based polysomnography; Wake and Sleep conditions were counterbalanced. Children with ASD had poorer sleep efficiency than controls, but other sleep macroarchitectural and microarchitectural measures were comparable after controlling for age and medication use. Both groups demonstrated better memory consolidation across Sleep than Wake, although participants with ASD had poorer overall memory consolidation than controls. There was no interaction between group and condition. The change in performance across sleep, independent of medication and age, showed no significant relationships with any specific sleep parameters other than total sleep time and showed a trend toward less forgetting in the control group. CONCLUSION: This study shows that despite their more disturbed sleep quality, children with autism spectrum disorder (ASD) still demonstrate more stable memory consolidation across sleep than in wake conditions. The findings support the importance of sleep for stabilizing memory in children with and without neurodevelopmental disabilities. Our results suggest that improving sleep quality in children with ASD could have direct benefits to improving their overall cognitive functioning.
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