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Literature DB >> 26194480

B cells in the aging immune system: time to consider B-1 cells.

Nichol E Holodick¹, Thomas L Rothstein^1,2.

Abstract

The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B-1 cell subset is an essential arm of the innate immune system, which in general has been understudied in terms of immune senescence. Here, we review what is currently known about B cells during aging and go on to describe why B-1 cell biology is an important component of the aging immune system in the context of diseases that most affect the aged population.

Entities: Chemical Disease Gene Species

Keywords: B cells; B-1 cells; aging; senescence

Mesh：

Substances：

Year: 2015 PMID： 26194480 PMCID： PMC4679494 DOI： 10.1111/nyas.12825

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

89 in total

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17 in total

Review 1. The role of B-1 cells in inflammation.

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Journal: Aging Cell Date: 2021-07-19 Impact factor: 9.304