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Literature DB >> 2619306

Aromatic hydroxylation and sulfation of 5-hydroxyflavone by Streptomyces fulvissimus.

Abstract

The conversion of 5-hydroxyflavone by various microorganisms was studied. Among them, Streptomyces fulvissimus was the sole microbe which produced a new polar metabolite from 5-hydroxyflavone in addition to 5,4-dihydoxy- and 5,3,4-trihydroxyflavone. The structure of this polar metabolite was determined to be 5,4-dihydroxyflavone-4-sulfate on the basis of mass, infrared, and nuclear magnetic resonance spectroscopies. These results demonstrate that S. fulvissimus catalyzes sulfation at the 4 position of 4,5-dihydroxyflavone.

Entities: Chemical Species

Mesh：

Substances：

Year: 1989 PMID： 2619306 PMCID： PMC203236 DOI： 10.1128/aem.55.12.3140-3142.1989

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

14 in total

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6. Use of a mammalian cell culture benzo(a)pyrene metabolism assay for the detection of potential anticarcinogens from natural products: inhibition of metabolism by biochanin A, an isoflavone from Trifolium pratense L.

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Journal: Cancer Res Date: 1988-11-15 Impact factor: 12.701

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Authors: A M Hackett; L A Griffiths; M Wermeille
Journal: Xenobiotica Date: 1985-11 Impact factor: 1.908

8. Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships.

Authors: C A Elliger; P R Henika; J T MacGregor
Journal: Mutat Res Date: 1984-02 Impact factor: 2.433

Aromatic hydroxylation and sulfation of 5-hydroxyflavone by Streptomyces fulvissimus.

1. Phytoestrogen interaction with estrogen receptors in human breast cancer cells.

Review 2. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

Review 3. Naturally occurring food toxicants: phenolic substances of plant origin common in foods.

4. Antiviral effect of flavonoids on human viruses.

5. Mutagenic activity of quercetin and related compounds.

6. Use of a mammalian cell culture benzo(a)pyrene metabolism assay for the detection of potential anticarcinogens from natural products: inhibition of metabolism by biochanin A, an isoflavone from Trifolium pratense L.

7. The quantitative disposition of 3-O-methyl-(+)-[U-14C]catechin in man following oral administration.

8. Mutagenicity of flavones, chromones and acetophenones in Salmonella typhimurium. New structure-activity relationships.

9. The metabolism and excretion of 3-palmitoyl-(+)-catechin in the rat.

10. Glucuronide and sulfate conjugation in the fungal metabolism of aromatic hydrocarbons.

1. Biotransformation of puerarin into puerarin-6″-O-phosphate by Bacillus cereus.

2. Microbial transformation of zearalenone to a zearalenone sulfate.

3. Flavone Biotransformation by Aspergillus niger and the Characterization of Two Newly Formed Metabolites.

Review 4. Improved release and metabolism of flavonoids by steered fermentation processes: a review.

Review 5. Reviewing a plethora of oxidative-type reactions catalyzed by whole cells of Streptomyces species.