Literature DB >> 26191200

High-grade ovarian cancer secreting effective exosomes in tumor angiogenesis.

Huan Yi1, Jun Ye2, Xiao-Mei Yang3, Li-Wen Zhang2, Zhi-Gang Zhang3, Ya-Ping Chen2.   

Abstract

Ovarian cancer, the most lethal gynecological cancer, related closely to tumor stage. High-grade ovarian cancer always results in a late diagnose and high recurrence, which reduce survival within five years. Until recently, curable therapy is still under research and anti-angiogenesis proves a promising way. Tumor-derived exosomes are essential in tumor migration and metastases such as angiogenesis is enhanced by exosomes. In our study, we have made comparison between high-grade and unlikely high-grade serous ovarian cancer cells on exosomal function of endothelial cells proliferation, migration and tube formation. Exosomes derived from high-grade ovarian cancer have a profound impact on angiogenesis with comparison to unlikely high-grade ovarian cancer. Proteomic profiles revealed some potential proteins involved in exosomal function of angiogenesis such as ATF2, MTA1, ROCK1/2 and so on. Therefore, exosomes plays an influential role in angiogenesis in ovarian serous cancer and also function more effectively in high-grade ovarian cancer cells.

Entities:  

Keywords:  Ovarian cancerexosome; angiogenesis; proteomic profiles

Mesh：

Substances：

Year:  2015        PMID： 26191200      PMCID： PMC4503072     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  23 in total

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Journal:  J Biochem       Date:  2006-07       Impact factor: 3.387

2.  Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1.

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Journal:  Blood       Date:  2014-10-15       Impact factor: 22.113

3.  Dysregulated cell mechanical properties of endometrial stromal cells from endometriosis patients.

Authors:  Zhi-Yong Wu; Xiao-Mei Yang; Ming-Jun Cheng; Rong Zhang; Jun Ye; Huan Yi; Jun-Ping Ao; Zhi-Gang Zhang; Cong-Jian Xu
Journal:  Int J Clin Exp Pathol       Date:  2014-01-15

4.  Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro.

Authors:  John D O'Neil; Thomas J Owen; Victoria H J Wood; Kathryn L Date; Robert Valentine; Marilyn B Chukwuma; John R Arrand; Christopher W Dawson; Lawrence S Young
Journal:  J Gen Virol       Date:  2008-11       Impact factor: 3.891

5.  Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.

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Journal:  Cancer Cell       Date:  2014-04-14       Impact factor: 31.743

6.  Programmed cell death 4 and microRNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions.

Authors:  Rocco Cappellesso; Andrea Tinazzi; Thomas Giurici; Francesca Simonato; Vincenza Guzzardo; Laura Ventura; Marika Crescenzi; Silvia Chiarelli; Ambrogio Fassina
Journal:  Cancer Cytopathol       Date:  2014-05-28       Impact factor: 5.284

7.  Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

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Journal:  N Engl J Med       Date:  2012-03-08       Impact factor: 91.245

8.  ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression.

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Journal:  Curr Mol Med       Date:  2013-01       Impact factor: 2.222

9.  Exosomal Proteome Profiling: A Potential Multi-Marker Cellular Phenotyping Tool to Characterize Hypoxia-Induced Radiation Resistance in Breast Cancer.

Authors:  Stefani N Thomas; Zhongping Liao; David Clark; Yangyi Chen; Ramin Samadani; Li Mao; David K Ann; Janet E Baulch; Paul Shapiro; Austin J Yang
Journal:  Proteomes       Date:  2013-09-01

Review 10.  Exosome function: from tumor immunology to pathogen biology.

Authors:  Jeffrey S Schorey; Sanchita Bhatnagar
Journal:  Traffic       Date:  2008-03-06       Impact factor: 6.215
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  32 in total

1.  Exosomes mediated pentose phosphate pathway in ovarian cancer metastasis: a proteomics analysis.

Authors:  Huan Yi; Xiangqin Zheng; Jianrong Song; Rongkai Shen; Yanzhao Su; Danmei Lin
Journal:  Int J Clin Exp Pathol       Date:  2015-12-01

2.  Exosomes as a novel pathway for regulating development and diseases of the skin.

Authors:  Ying Liu; Haidong Wang; Juan Wang
Journal:  Biomed Rep       Date:  2018-01-31

3.  * Glioblastoma Exosomes for Therapeutic Angiogenesis in Peripheral Ischemia.

Authors:  Anthony Monteforte; Brian Lam; Michael B Sherman; Kayla Henderson; Andrew D Sligar; Adrianne Spencer; Brian Tang; Andrew K Dunn; Aaron B Baker
Journal:  Tissue Eng Part A       Date:  2017-11       Impact factor: 3.845

Review 4.  Emerging role of exosomes in cancer progression and tumor microenvironment remodeling.

Authors:  Mahshid Deldar Abad Paskeh; Maliheh Entezari; Sepideh Mirzaei; Amirhossein Zabolian; Hossein Saleki; Mohamad Javad Naghdi; Sina Sabet; Mohammad Amin Khoshbakht; Mehrdad Hashemi; Kiavash Hushmandi; Gautam Sethi; Ali Zarrabi; Alan Prem Kumar; Shing Cheng Tan; Marios Papadakis; Athanasios Alexiou; Md Asiful Islam; Ebrahim Mostafavi; Milad Ashrafizadeh
Journal:  J Hematol Oncol       Date:  2022-06-28       Impact factor: 23.168

5.  A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ.

Authors:  Jenette Creaney; Ian M Dick; Justine S Leon; Bruce W S Robinson
Journal:  Cancer Genomics Proteomics       Date:  2017 Mar-Apr       Impact factor: 4.069

Review 6.  Exosomes for Immunoregulation and Therapeutic Intervention in Cancer.

Authors:  Xuan Zhang; Zenglin Pei; Jinyun Chen; Chunxia Ji; Jianqing Xu; Xiaoyan Zhang; Jin Wang
Journal:  J Cancer       Date:  2016-05-25       Impact factor: 4.207

Review 7.  Tumor-derived exosomes in ovarian cancer - liquid biopsies for early detection and real-time monitoring of cancer progression.

Authors:  Shayna Sharma; Felipe Zuñiga; Gregory E Rice; Lewis C Perrin; John D Hooper; Carlos Salomon
Journal:  Oncotarget       Date:  2017-10-31

8.  TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer.

Authors:  Meiying Zhang; Guanglei Zhuang; Xiangjun Sun; Yanying Shen; Wenjing Wang; Qing Li; Wen Di
Journal:  Diagn Pathol       Date:  2017-02-02       Impact factor: 2.644

Review 9.  The emerging roles and therapeutic potential of exosomes in epithelial ovarian cancer.

Authors:  Xiaoduan Li; Xipeng Wang
Journal:  Mol Cancer       Date:  2017-05-15       Impact factor: 27.401

10.  The potential role of tumor-derived exosomes in diagnosis, prognosis, and response to therapy in cancer.

Authors:  Malgorzata Czystowska-Kuzmicz; Theresa L Whiteside
Journal:  Expert Opin Biol Ther       Date:  2020-09-08       Impact factor: 4.388
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