| Literature DB >> 26191181 |
Shouping Xu1, Shiyao Sui1, Jinfeng Zhang1, Nanxia Bai1, Qingyu Shi1, Guangwen Zhang2, Song Gao1, Zilong You1, Chao Zhan1, Feng Liu1, Da Pang3.
Abstract
The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) regulates cell motility via the transcriptional or post-transcriptional control of motility-related genes. Whether MALAT1 plays a critical role in cancer progression in breast cancer remains unclear. In this study, we found that MALAT1 was downregulated in breast tumor cell lines and cancer tissue, and showed that knockdown of MALAT1 in breast cancer cell lines induced an epithelial-to-mesenchymal transition (EMT) program via phosphatidylinositide-3 kinase-AKT pathways. Furthermore, lower expression of MALAT1 in breast cancer patients was associated with shorter relapse-free survival. Thus, our results indicate for the first time that MALAT1 is a novel regulator of EMT in breast cancer and may be a potential therapeutic target for breast cancer metastasis.Entities:
Keywords: EMT; Long noncoding RNA; MALAT1; breast cancer; metastasis
Mesh：
Substances：
Year: 2015 PMID： 26191181 PMCID： PMC4503053
Source DB: PubMed Journal: Int J Clin Exp Pathol ISSN： 1936-2625