Literature DB >> 26187956

A Complex Signaling Cascade Governs Pristinamycin Biosynthesis in Streptomyces pristinaespiralis.

Yvonne Mast1, Jamil Guezguez2, Franziska Handel2, Eva Schinko2.   

Abstract

Pristinamycin production in Streptomyces pristinaespiralis Pr11 is tightly regulated by an interplay between different repressors and activators. A γ-butyrolactone receptor gene (spbR), two TetR repressor genes (papR3 and papR5), three SARP (Streptomyces antibiotic regulatory protein) genes (papR1, papR2, and papR4), and a response regulator gene (papR6) are carried on the large 210-kb pristinamycin biosynthetic gene region of Streptomyces pristinaespiralis Pr11. A detailed investigation of all pristinamycin regulators revealed insight into a complex signaling cascade, which is responsible for the fine-tuned regulation of pristinamycin production in S. pristinaespiralis.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26187956      PMCID： PMC4561715          DOI： 10.1128/AEM.00728-15

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  51 in total

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Review 3.  Regulation of secondary metabolism in streptomycetes.

Authors:  Mervyn J Bibb
Journal:  Curr Opin Microbiol       Date:  2005-04       Impact factor: 7.934

Review 4.  The TetR family of transcriptional repressors.

Authors:  Juan L Ramos; Manuel Martínez-Bueno; Antonio J Molina-Henares; Wilson Terán; Kazuya Watanabe; Xiaodong Zhang; María Trinidad Gallegos; Richard Brennan; Raquel Tobes
Journal:  Microbiol Mol Biol Rev       Date:  2005-06       Impact factor: 11.056

Review 5.  Antibiotic production by actinomycetes: the Janus faces of regulation.

Authors:  Eric Cundliffe
Journal:  J Ind Microbiol Biotechnol       Date:  2006-02-07       Impact factor: 3.346

6.  Searching for patterns in genomic data.

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7.  Characterization of binding sequences for butyrolactone autoregulator receptors in streptomycetes.

Authors:  H Kinoshita; T Tsuji; H Ipposhi; T Nihira; Y Yamada
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

8.  Regulation of tylosin production: role of a TylP-interactive ligand.

Authors:  Dawn R D Bignell; Neil Bate; Eric Cundliffe
Journal:  Mol Microbiol       Date:  2006-12-20       Impact factor: 3.501

9.  Purification and characterization of the DNA-binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius.

Authors:  L Tang; A Grimm; Y X Zhang; C R Hutchinson
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Authors:  Renata Novakova; Dagmar Homerova; Lubomira Feckova; Jan Kormanec
Journal:  Microbiology       Date:  2005-08       Impact factor: 2.777
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  8 in total

Review 1.  Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces.

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3.  Functional investigation of AfsKRS regulatory system for pristinamycin biosynthesis in Streptomyces pristinaespiralis.

Authors:  Qingchao Jin; Haipeng Liao; Yanping Dou; Na Shen; Zhige Wu; Yu Yang; Zhihua Jin
Journal:  3 Biotech       Date:  2021-08-23       Impact factor: 2.893

4.  Improvement of pristinamycin I (PI) production in Streptomyces pristinaespiralis by metabolic engineering approaches.

Authors:  Jiali Meng; Rongrong Feng; Guosong Zheng; Mei Ge; Yvonne Mast; Wolfgang Wohlleben; Jufang Gao; Weihong Jiang; Yinhua Lu
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5.  The Streptomyces filipinensis Gamma-Butyrolactone System Reveals Novel Clues for Understanding the Control of Secondary Metabolism.

Authors:  Eva G Barreales; Tamara D Payero; Ester Jambrina; Jesús F Aparicio
Journal:  Appl Environ Microbiol       Date:  2020-09-01       Impact factor: 4.792

Review 6.  Regulation of antibiotic biosynthesis in actinomycetes: Perspectives and challenges.

Authors:  Junhong Wei; Lang He; Guoqing Niu
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7.  Genetic engineering approaches for the fermentative production of phenylglycines.

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Journal:  Appl Microbiol Biotechnol       Date:  2020-02-20       Impact factor: 4.813

Review 8.  The Application of Regulatory Cascades in Streptomyces: Yield Enhancement and Metabolite Mining.

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Journal:  Front Microbiol       Date:  2020-03-24       Impact factor: 5.640
  8 in total

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