OBJECTIVE: To explore the diagnostic value of single-source dual-energy spectral CT (sDECT) imaging in an acute superior mesenteric artery embolus (SMAE) canine model. METHODS: Pre-contrast and double-phase contrast-enhanced sDECT were performed before and after embolization in eight SMAE dog models. Monochromatic images of embolized intestine with the best contrast-to-noise ratio (CNR) were obtained and compared with the polychromatic images. CT parameters including attenuation value, iodine content, water content and thickness of the embolized intestinal segments were obtained, and normalized difference in iodine concentration (NDIC) was calculated. RESULTS: The CNR in pre-contrast, arterial phase and portal venous phase at 4 h after embolization was 1.11 ± 1.23, 13.50 ± 1.54 and 10.63 ± 3.75, respectively, significantly higher than those of the polychromatic images (p < 0.05). The iodine-based images clearly revealed the embolized intestinal segments, which were highly consistent with the gross findings. The difference in attenuation values between the embolization area and non-embolization area in the monochromatic images was 105.06 ± 35.35 HU, higher than that in the polychromatic images (p < 0.001). The attenuation values and NDIC were significantly decreased at 2 h after embolization, relatively increased at 4 h and gradually decreased at 6 and 8 h. The changing pattern of thickness was similar to that of NDIC over time after embolization. CONCLUSION: sDECT can provide the optimal monochromatic images and allow increased detection rates of lesions. sDECT is a very promising tool for quantitative diagnosis of SMAE. ADVANCES IN KNOWLEDGE: Our research provides more quantitative parameters for the assessment of SMAE by sDECT.
OBJECTIVE: To explore the diagnostic value of single-source dual-energy spectral CT (sDECT) imaging in an acute superior mesenteric artery embolus (SMAE) canine model. METHODS: Pre-contrast and double-phase contrast-enhanced sDECT were performed before and after embolization in eight SMAE dog models. Monochromatic images of embolized intestine with the best contrast-to-noise ratio (CNR) were obtained and compared with the polychromatic images. CT parameters including attenuation value, iodine content, water content and thickness of the embolized intestinal segments were obtained, and normalized difference in iodine concentration (NDIC) was calculated. RESULTS: The CNR in pre-contrast, arterial phase and portal venous phase at 4 h after embolization was 1.11 ± 1.23, 13.50 ± 1.54 and 10.63 ± 3.75, respectively, significantly higher than those of the polychromatic images (p < 0.05). The iodine-based images clearly revealed the embolized intestinal segments, which were highly consistent with the gross findings. The difference in attenuation values between the embolization area and non-embolization area in the monochromatic images was 105.06 ± 35.35 HU, higher than that in the polychromatic images (p < 0.001). The attenuation values and NDIC were significantly decreased at 2 h after embolization, relatively increased at 4 h and gradually decreased at 6 and 8 h. The changing pattern of thickness was similar to that of NDIC over time after embolization. CONCLUSION:sDECT can provide the optimal monochromatic images and allow increased detection rates of lesions. sDECT is a very promising tool for quantitative diagnosis of SMAE. ADVANCES IN KNOWLEDGE: Our research provides more quantitative parameters for the assessment of SMAE by sDECT.
Authors: Alvin C Silva; Brian G Morse; Amy K Hara; Robert G Paden; Norio Hongo; William Pavlicek Journal: Radiographics Date: 2011 Jul-Aug Impact factor: 5.333
Authors: Jin Peng; Long Jiang Zhang; U Joseph Schoepf; Kevin P Gibbs; Heng Shan Ji; Gui Fen Yang; Hong Zhu; Guang Ming Lu Journal: Acta Radiol Date: 2013-04-01 Impact factor: 1.990
Authors: Juergen Fornaro; Sebastian Leschka; Dennis Hibbeln; Anthony Butler; Nigel Anderson; Gregor Pache; Hans Scheffel; Simon Wildermuth; Hatem Alkadhi; Paul Stolzmann Journal: Insights Imaging Date: 2011-01-19