Patricia A Cioe1, Jason Baker, Erna M Kojic, Nur Onen, John Hammer, Pragna Patel, Christopher W Kahler. 1. *Center for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, RI; †Department of Medicine, University of Minnesota, Hennepin County Medical Center, Minneapolis, MN; ‡Department of Infectious Disease, Brown University, Providence, RI; §Washington University School of Medicine in St. Louis, St. Louis, MO; ‖Denver Infectious Disease Consultants, Denver, CO; and ¶Centers for Disease Control and Prevention, Atlanta, GA.
Abstract
BACKGROUND: Persons living with HIV are at increased risk for cardiovascular disease in part because of persistent inflammation and coagulation activation. METHODS: We examined whether smoking and heavy episodic alcohol use (defined as 5 or more drinks on one occasion) were associated with greater monocyte activation (soluble CD14) and coagulation (D-dimer) in participants in the Study to Understand the Natural History of HIV and AIDS in the Era of Effective Therapy (the "SUN" Study), a prospective observational cohort. RESULTS: Using regression analysis (n = 689), current smoking compared with nonsmoking was associated with significantly elevated soluble CD14 (B = 135.57, 95% confidence interval: 84.95 to 186.19, P < 0.001), whereas heavy alcohol use compared with nonheavy use was associated with significantly lower D-dimer levels (B = -0.059, 95% confidence interval: -0.102 to -0.016, P = 0.007). CONCLUSIONS: Smoking cessation should be encouraged by HIV care providers to improve mortality outcomes from all causes of death, particularly cardiovascular disease.
BACKGROUND:Persons living with HIV are at increased risk for cardiovascular disease in part because of persistent inflammation and coagulation activation. METHODS: We examined whether smoking and heavy episodic alcohol use (defined as 5 or more drinks on one occasion) were associated with greater monocyte activation (soluble CD14) and coagulation (D-dimer) in participants in the Study to Understand the Natural History of HIV and AIDS in the Era of Effective Therapy (the "SUN" Study), a prospective observational cohort. RESULTS: Using regression analysis (n = 689), current smoking compared with nonsmoking was associated with significantly elevated soluble CD14 (B = 135.57, 95% confidence interval: 84.95 to 186.19, P < 0.001), whereas heavy alcohol use compared with nonheavy use was associated with significantly lower D-dimer levels (B = -0.059, 95% confidence interval: -0.102 to -0.016, P = 0.007). CONCLUSIONS: Smoking cessation should be encouraged by HIV care providers to improve mortality outcomes from all causes of death, particularly cardiovascular disease.
Authors: Frank H Galvan; Eric G Bing; John A Fleishman; Andrew S London; Raul Caetano; M Audrey Burnam; Doug Longshore; Sally C Morton; Maria Orlando; Martin Shapiro Journal: J Stud Alcohol Date: 2002-03
Authors: Marlien Pieters; Hester H Vorster; Johann C Jerling; Christine S Venter; Retha C M Kotze; Elsabe Bornman; Joyce J M C Malfliet; Dingeman C Rijken Journal: Thromb Haemost Date: 2010-07-20 Impact factor: 5.249
Authors: Rachel M Presti; Sonia C Flores; Brent E Palmer; Jeffrey J Atkinson; Catherine R Lesko; Bryan Lau; Andrew P Fontenot; Jesse Roman; John F McDyer; Homer L Twigg Journal: Chest Date: 2017-04-17 Impact factor: 9.410
Authors: Mollie A Monnig; Christopher W Kahler; Patricia A Cioe; Lynne Tucker; Peter M Monti; Kenneth H Mayer; Bharat Ramratnam Journal: AIDS Care Date: 2016-05-30
Authors: Jessica L Montoya; Jennifer Iudicello; Hannah A Oppenheim; Pariya L Fazeli; Michael Potter; Qing Ma; Paul J Mills; Ronald J Ellis; Igor Grant; Scott L Letendre; David J Moore Journal: AIDS Date: 2017-03-27 Impact factor: 4.177
Authors: Andrea H Weinberger; Philip H Smith; Allison P Funk; Shayna Rabin; Jonathan Shuter Journal: J Acquir Immune Defic Syndr Date: 2017-04-01 Impact factor: 3.731
Authors: Emily C Williams; Judith A Hahn; Richard Saitz; Kendall Bryant; Marlene C Lira; Jeffrey H Samet Journal: Alcohol Clin Exp Res Date: 2016-09-22 Impact factor: 3.455
Authors: Tatt Jhong Haw; Malcolm R Starkey; Stelios Pavlidis; Michael Fricker; Anya L Arthurs; Prema M Nair; Gang Liu; Irwan Hanish; Richard Y Kim; Paul S Foster; Jay C Horvat; Ian M Adcock; Philip M Hansbro Journal: Am J Physiol Lung Cell Mol Physiol Date: 2017-10-12 Impact factor: 5.464