Literature DB >> 20473559

A highly selective fluorescent probe for detection of biological samples thiol and its application in living cells.

Qing-Ping Zuo1, Bing Li, Qi Pei, Zuojun Li, Shi-Kun Liu.   

Abstract

Probe 1 was designed and synthesized as a new fluorescent molecular probe for thiols in PBS buffer at physiological condition. This fluorescent molecular probe consists of a thiol reaction moiety bound to a coumarin fluorophore. Its fluorescence quantum yield is low, but a drastic enhancement of fluorescence intensity was observed in the presence of thiols. Possible interference with other analytes was examined. Probe 1 displays a highly selective fluorescent enhancement with thiols, and the probe was successfully applied to thiols determination in intracellular, in human urine and blood samples.

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Year:  2010        PMID： 20473559     DOI： 10.1007/s10895-010-0673-6

Source DB:  PubMed          Journal:  J Fluoresc        ISSN： 1053-0509            Impact factor:   2.217


  37 in total

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  5 in total

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5.  Spectral Properties of Highly Emissive Derivative of Coumarin with N,N-Diethylamino, Nitrile and Tiophenecarbonyl Moieties in Water-Methanol Mixture.

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  5 in total

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