Roy L Soiza1,2, Kirsten Cumming2, Allan B Clark3, Joao H Bettencourt-Silva4, Anthony K Metcalf3,4, Kristian M Bowles3,4, John F Potter3,4, Phyo K Myint1,2,3,4. 1. Department of Geriatric Medicine, Aberdeen Royal Infirmary, Aberdeen, Scotland, UK. 2. School of Medicine & Dentistry, University of Aberdeen, Aberdeen, Scotland, UK. 3. Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK. 4. Stroke Research Group, Norfolk & Norwich University Hospital, Norwich, Norfolk, UK.
Abstract
BACKGROUND: Hyponatremia, the commonest electrolyte imbalance encountered in clinical practice, is associated with adverse outcomes. Despite this, understanding of the association between hyponatremia and stroke mortality outcome is limited. AIMS: To investigate the association between admission serum sodium and mortality at various time-points after stroke. METHODS: Cases of acute stroke admitted to Norfolk and Norwich University Hospital consecutively from January 2003 until June 2013 were included, with mortality outcomes ascertained until the end of December 2013. Odds ratios or hazards ratios for death were constructed for various time-points (within seven-days, 8-30 days, within one-year, and over full follow-up). RESULTS: There were 8540 participants included (47·4% male, mean age 77·3 (±12·0) years). Point prevalence of hypernatremia and hyponatremia were 3·3% and 13·8%, respectively. In fully adjusted models controlling for age, gender, prestroke modified Rankin score, stroke type, Oxford community stroke project class, and laboratory biochemical and hematological results, the odds ratio (up to one-year)/hazards ratio (for full follow-up) for the above time-points were 1·00, 1·11, 1·03, 1·05 for mild hyponatremia; 1·97, 0·78, 1·11, 1·2 for moderate hyponatremia; 3·31, 1·57, 2·45, 1·67 for severe hyponatremia; and 0·47, 1·23, 1·30, 1·10 for hypernatremia. When stratified by age groups, outcomes were poorer in younger hyponatremic patients (aged <75 years). CONCLUSION: Hyponatremia is prevalent in acute stroke admissions and is independently associated with higher mortality in patients <75 years.
BACKGROUND:Hyponatremia, the commonest electrolyte imbalance encountered in clinical practice, is associated with adverse outcomes. Despite this, understanding of the association between hyponatremia and stroke mortality outcome is limited. AIMS: To investigate the association between admission serum sodium and mortality at various time-points after stroke. METHODS: Cases of acute stroke admitted to Norfolk and Norwich University Hospital consecutively from January 2003 until June 2013 were included, with mortality outcomes ascertained until the end of December 2013. Odds ratios or hazards ratios for death were constructed for various time-points (within seven-days, 8-30 days, within one-year, and over full follow-up). RESULTS: There were 8540 participants included (47·4% male, mean age 77·3 (±12·0) years). Point prevalence of hypernatremia and hyponatremia were 3·3% and 13·8%, respectively. In fully adjusted models controlling for age, gender, prestroke modified Rankin score, stroke type, Oxford community stroke project class, and laboratory biochemical and hematological results, the odds ratio (up to one-year)/hazards ratio (for full follow-up) for the above time-points were 1·00, 1·11, 1·03, 1·05 for mild hyponatremia; 1·97, 0·78, 1·11, 1·2 for moderate hyponatremia; 3·31, 1·57, 2·45, 1·67 for severe hyponatremia; and 0·47, 1·23, 1·30, 1·10 for hypernatremia. When stratified by age groups, outcomes were poorer in younger hyponatremic patients (aged <75 years). CONCLUSION:Hyponatremia is prevalent in acute stroke admissions and is independently associated with higher mortality in patients <75 years.
Authors: Sarah R Martha; Lisa A Collier; Stephanie M Davis; Sarah J Goodwin; David Powell; Doug Lukins; Justin F Fraser; Keith R Pennypacker Journal: J Neurosci Res Date: 2019-04-03 Impact factor: 4.164
Authors: Sarah R Martha; Lisa A Collier; Stephanie M Davis; Hilary A Seifert; Christopher C Leonardo; Craig T Ajmo; Elspeth A Foran; Justin F Fraser; Keith R Pennypacker Journal: J Stroke Cerebrovasc Dis Date: 2018-07-29 Impact factor: 2.136
Authors: David J McLernon; Phyo K Myint; Weronika A Szlachetka; Tiberiu A Pana; Mamas A Mamas; Joao H Bettencourt-Silva; Anthony K Metcalf; John F Potter Journal: Acta Neurol Belg Date: 2021-08-18 Impact factor: 2.471