| Literature DB >> 26178441 |
Josep Saurí1, Wolfgang Bermel2, Alexei V Buevich1, Edward C Sherer1, Leo A Joyce1, Maged H M Sharaf3, Paul L Schiff4, Teodor Parella5, R Thomas Williamson1, Gary E Martin6.
Abstract
Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1,n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.Entities:
Keywords: DFT calculations; HD-ADEQUATE; NMR spectroscopy; cryptolepis alkaloids; homodecoupling
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Year: 2015 PMID： 26178441 DOI： 10.1002/anie.201502540
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336