Hyun Seok Choi1, Sung Soo Ahn2, Na-Young Shin2, Jinna Kim2, Jae Hyung Kim3, Jong Eun Lee4, Hye Yeon Lee1, Ji Hoe Heo5, Seung-Koo Lee2. 1. Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea. 2. Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, Korea. 3. Department of Radiology, College of Medicine, Seoul National University, Seoul 110-744, Korea. 4. Department of Anatomy, College of Medicine, Yonsei University, Seoul 120-752, Korea. 5. Department of Neurology, College of Medicine, Yonsei University, Seoul 120-752, Korea.
Abstract
OBJECTIVE: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. MATERIALS AND METHODS: Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (K(trans), ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue. RESULTS: All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001). CONCLUSION: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and K(trans) shows the strongest correlation among the tested parameters.
OBJECTIVE: The purpose of this study was to correlate permeability parameters measured with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using a clinical 3-tesla scanner with extravasation of Evans blue in a rat model with transient cerebral ischemia. MATERIALS AND METHODS:Sprague-Dawley rats (n = 13) with transient middle cerebral artery occlusion were imaged using a 3-tesla MRI with an 8-channel wrist coil. DCE-MRI was performed 12 hours, 18 hours, and 36 hours after reperfusion. Permeability parameters (K(trans), ve, and vp) from DCE-MRI were calculated. Evans blue was injected after DCE-MRI and extravasation of Evans blue was correlated as a reference with the integrity of the blood-brain barrier. Correlation analysis was performed between permeability parameters and the extravasation of Evans blue. RESULTS: All permeability parameters (K(trans), ve, and vp) showed a linear correlation with extravasation of Evans blue. Among them, K(trans) showed highest values of both the correlation coefficient and the coefficient of determination (0.687 and 0.473 respectively, p < 0.001). CONCLUSION: Permeability parameters obtained by DCE-MRI at 3-T are well-correlated with Evans blue extravasation, and K(trans) shows the strongest correlation among the tested parameters.
Authors: David Tanne; Scott E Kasner; Andrew M Demchuk; Nira Koren-Morag; Sandra Hanson; Martin Grond; Steven R Levine Journal: Circulation Date: 2002-04-09 Impact factor: 29.690
Authors: C S Kase; A J Furlan; L R Wechsler; R T Higashida; H A Rowley; R G Hart; G F Molinari; L S Frederick; H C Roberts; J M Gebel; C A Sila; G A Schulz; R S Roberts; M Gent Journal: Neurology Date: 2001-11-13 Impact factor: 9.910