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Literature DB >> 26175409

Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition.

C Allison Stewart¹, Lauren Averett Byers².

Abstract

In this issue of Cancer Cell, Mohammad et al. describe LSD1, a histone demethylase, as a therapeutic target in SCLC with a unique epigenetic signature to predict drug sensitivity. Inhibition of LSD1 reduces cell proliferation and stem cell maintenance while promoting cell differentiation and reducing tumor growth in preclinical models.

Entities: Chemical Disease Gene Species

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Year: 2015 PMID： 26175409 PMCID： PMC5497474 DOI： 10.1016/j.ccell.2015.06.011

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

10 in total

Review 1. The future of epigenetic therapy in solid tumours--lessons from the past.

Authors: Nilofer Azad; Cynthia A Zahnow; Charles M Rudin; Stephen B Baylin
Journal: Nat Rev Clin Oncol Date: 2013-04-02 Impact factor: 66.675

2. LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.

Authors: Antonio Adamo; Borja Sesé; Stephanie Boue; Julio Castaño; Ida Paramonov; Maria J Barrero; Juan Carlos Izpisua Belmonte
Journal: Nat Cell Biol Date: 2011-05-22 Impact factor: 28.824

3. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.

Authors: James P Sullivan; Monica Spinola; Michael Dodge; Maria G Raso; Carmen Behrens; Boning Gao; Katja Schuster; Chunli Shao; Jill E Larsen; Laura A Sullivan; Sofia Honorio; Yang Xie; Pier P Scaglioni; J Michael DiMaio; Adi F Gazdar; Jerry W Shay; Ignacio I Wistuba; John D Minna
Journal: Cancer Res Date: 2010-11-30 Impact factor: 12.701

4. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.

Authors: William J Harris; Xu Huang; James T Lynch; Gary J Spencer; James R Hitchin; Yaoyong Li; Filippo Ciceri; Julian G Blaser; Brigit F Greystoke; Allan M Jordan; Crispin J Miller; Donald J Ogilvie; Tim C P Somervaille
Journal: Cancer Cell Date: 2012-03-29 Impact factor: 31.743

5. Lysine methylation regulates E2F1-induced cell death.

Authors: Haroula Kontaki; Iannis Talianidis
Journal: Mol Cell Date: 2010-07-09 Impact factor: 17.970

6. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Authors: Martin Peifer; Lynnette Fernández-Cuesta; Martin L Sos; Julie George; Danila Seidel; Lawryn H Kasper; Dennis Plenker; Frauke Leenders; Ruping Sun; Thomas Zander; Roopika Menon; Mirjam Koker; Ilona Dahmen; Christian Müller; Vincenzo Di Cerbo; Hans-Ulrich Schildhaus; Janine Altmüller; Ingelore Baessmann; Christian Becker; Bram de Wilde; Jo Vandesompele; Diana Böhm; Sascha Ansén; Franziska Gabler; Ines Wilkening; Stefanie Heynck; Johannes M Heuckmann; Xin Lu; Scott L Carter; Kristian Cibulskis; Shantanu Banerji; Gad Getz; Kwon-Sik Park; Daniel Rauh; Christian Grütter; Matthias Fischer; Laura Pasqualucci; Gavin Wright; Zoe Wainer; Prudence Russell; Iver Petersen; Yuan Chen; Erich Stoelben; Corinna Ludwig; Philipp Schnabel; Hans Hoffmann; Thomas Muley; Michael Brockmann; Walburga Engel-Riedel; Lucia A Muscarella; Vito M Fazio; Harry Groen; Wim Timens; Hannie Sietsma; Erik Thunnissen; Egbert Smit; Daniëlle A M Heideman; Peter J F Snijders; Federico Cappuzzo; Claudia Ligorio; Stefania Damiani; John Field; Steinar Solberg; Odd Terje Brustugun; Marius Lund-Iversen; Jörg Sänger; Joachim H Clement; Alex Soltermann; Holger Moch; Walter Weder; Benjamin Solomon; Jean-Charles Soria; Pierre Validire; Benjamin Besse; Elisabeth Brambilla; Christian Brambilla; Sylvie Lantuejoul; Philippe Lorimier; Peter M Schneider; Michael Hallek; William Pao; Matthew Meyerson; Julien Sage; Jay Shendure; Robert Schneider; Reinhard Büttner; Jürgen Wolf; Peter Nürnberg; Sven Perner; Lukas C Heukamp; Paul K Brindle; Stefan Haas; Roman K Thomas
Journal: Nat Genet Date: 2012-09-02 Impact factor: 38.330

7. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.

Authors: Charles M Rudin; Steffen Durinck; Eric W Stawiski; John T Poirier; Zora Modrusan; David S Shames; Emily A Bergbower; Yinghui Guan; James Shin; Joseph Guillory; Celina Sanchez Rivers; Catherine K Foo; Deepali Bhatt; Jeremy Stinson; Florian Gnad; Peter M Haverty; Robert Gentleman; Subhra Chaudhuri; Vasantharajan Janakiraman; Bijay S Jaiswal; Chaitali Parikh; Wenlin Yuan; Zemin Zhang; Hartmut Koeppen; Thomas D Wu; Howard M Stern; Robert L Yauch; Kenneth E Huffman; Diego D Paskulin; Peter B Illei; Marileila Varella-Garcia; Adi F Gazdar; Frederic J de Sauvage; Richard Bourgon; John D Minna; Malcolm V Brock; Somasekar Seshagiri
Journal: Nat Genet Date: 2012-09-02 Impact factor: 38.330

8. Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer.

Authors: Tangfeng Lv; Dongmei Yuan; Xiaohui Miao; Yanling Lv; Ping Zhan; Xiaokun Shen; Yong Song
Journal: PLoS One Date: 2012-04-06 Impact factor: 3.240

9. DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2.

Authors: J T Poirier; E E Gardner; N Connis; A L Moreira; E de Stanchina; C L Hann; C M Rudin
Journal: Oncogene Date: 2015-03-09 Impact factor: 9.867

10. CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist.

Authors: Sana Sarvi; Alison C Mackinnon; Nicolaos Avlonitis; Mark Bradley; Robert C Rintoul; Doris M Rassl; Wei Wang; Stuart J Forbes; Christopher D Gregory; Tariq Sethi
Journal: Cancer Res Date: 2014-01-16 Impact factor: 12.701

10 in total

12 in total

Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition.

Review 1. The future of epigenetic therapy in solid tumours--lessons from the past.

2. LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.

3. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling.

4. The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.

5. Lysine methylation regulates E2F1-induced cell death.

6. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

7. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.

8. Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer.

9. DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2.

10. CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist.

Review 1. Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials.

2. LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity.

Review 3. Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials.

Review 4. Cancer stem cells in small cell lung cancer.

Review 5. Clinical and Biological Features of Neuroendocrine Prostate Cancer.

Review 6. Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy.

7. Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells.

Review 8. Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity.

Review 9. Targeting Lung Cancer Stem Cells: Research and Clinical Impacts.

Review 10. [Progress of Epigenetic Methylation in Lung Cancer Research].