| Literature DB >> 26174332 |
Peter Werner1, Dorothee Saur2, Vilia Zeisig1, Barbara Ettrich2, Marianne Patt1, Bernhard Sattler1, Thies Jochimsen1, Donald Lobsien3, Philipp M Meyer1, Florian Then Bergh2,4, Antje Dreyer4,5, Johannes Boltze5,6, Joseph Classen2, Dominik Fritzsch3, Karl-Titus Hoffmann3, Osama Sabri1, Henryk Barthel1.
Abstract
Prospective studies on magnetic resonance imaging (MRI)-guided systemic thrombolysis >4.5 hours after stroke onset did not reach their primary end points. It was discussed and observed in post hoc data re-assessment that this was partly because of limited MRI accuracy to measure critical hypoperfusion. We report the first cases of simultaneous [(15)O]H2O-positron emission tomography (PET)/MRI in stroke patients and an ovine model. Discrepancies between simultaneously obtained PET and MRI readouts were observed that might explain the above current limitations of stroke MRI. By offering highly complementary information, [(15)O]H2O-PET/MRI might help to identify critically hypoperfused tissue resulting in an improved patient stratification in thrombolysis trials.Entities:
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Year: 2015 PMID： 26174332 PMCID： PMC4640332 DOI： 10.1038/jcbfm.2015.158
Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN： 0271-678X Impact factor: 6.200