Literature DB >> 26171192

Neutrophil to lymphocyte ratio is an independent prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer.

Derya Kivrak Salim1, Hasan Mutlu1, Melek Karakurt Eryilmaz1, Ozan Salim2, Fatma Yalçin Musri1, Deniz Tural1, Şeyda Gündüz3, Hasan Şenol Coşkun1.   

Abstract

The neutrophil to lymphocyte ratio (NLR) has been widely investigated for its prognostic significance in cancer. In the present study, we aimed to determine whether NLR is a prognostic factor in patients with recurrent or metastatic head and neck squamous cell cancer (HNSCC). A total of 79 patients from the Akdeniz University database were retrospectively analyzed. The cut-off NLR was set at 2.93; patients with NLR >2.93 had a median overall survival (OS) of 12.1 months, whereas the median OS was not reached for patients with NLR ≤2.93 (P=0.027). On multivariate analysis, NLR and recurrence or metastatic site were found to be independent prognostic factors for OS (P=0.014 and P=0.002, respectively). Therefore, NLR was identified as an independent prognostic factor for OS in patients with recurrent or metastatic HNSCC.

Entities:  

Keywords:  head and neck cancer; neutrophil to lymphocyte ratio; prognosis; survival

Year:  2015        PMID： 26171192      PMCID： PMC4486905          DOI： 10.3892/mco.2015.557

Source DB:  PubMed          Journal:  Mol Clin Oncol        ISSN： 2049-9450


  20 in total

1.  Pretreatment levels of peripheral neutrophils and lymphocytes as independent prognostic factors in patients with nasopharyngeal carcinoma.

Authors:  Jian-Rong He; Guo-Ping Shen; Ze-Fang Ren; Han Qin; Cui Cui; Ying Zhang; Yi-Xin Zeng; Wei-Hua Jia
Journal:  Head Neck       Date:  2012-02-09       Impact factor: 3.147

2.  Systemic inflammatory markers as independent prognosticators of head and neck squamous cell carcinoma.

Authors:  Alipasha Rassouli; Joe Saliba; Roberto Castano; Michael Hier; Anthony G Zeitouni
Journal:  Head Neck       Date:  2014-04-15       Impact factor: 3.147

3.  Prognostic factors in patients with advanced hypopharyngeal squamous cell carcinoma treated with concurrent chemoradiotherapy.

Authors:  V Krstevska; I Stojkovski; B Zafirova-Ivanovska; S Crvenkova
Journal:  J BUON       Date:  2012 Apr-Jun       Impact factor: 2.533

4.  High neutrophil-to-lymphocyte ratio is an independent marker of poor disease-specific survival in patients with oral cancer.

Authors:  Christos Perisanidis; Gabriela Kornek; Paul W Pöschl; Daniel Holzinger; Katharina Pirklbauer; Christian Schopper; Rolf Ewers
Journal:  Med Oncol       Date:  2013-01-06       Impact factor: 3.064

5.  Cancer statistics, 2014.

Authors:  Rebecca Siegel; Jiemin Ma; Zhaohui Zou; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2014-01-07       Impact factor: 508.702

Review 6.  Profiling early head and neck cancer.

Authors:  Keith D Hunter; E Ken Parkinson; Paul R Harrison
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7.  Correlation between the pretherapeutic neutrophil to lymphocyte ratio and the pathologic response to neoadjuvant chemotherapy in patients with advanced esophageal cancer.

Authors:  Hiroshi Sato; Yasuhiro Tsubosa; Tatsuyuki Kawano
Journal:  World J Surg       Date:  2012-03       Impact factor: 3.352

8.  Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer.

Authors:  Yu-Duan Tsai; Chao-Ping Wang; Chih-Yu Chen; Li-Wen Lin; Tzer-Zen Hwang; Li-Fen Lu; Hsia-Fen Hsu; Fu-Mei Chung; Yau-Jiunn Lee; Jer-Yiing Houng
Journal:  Head Neck       Date:  2014-01-16       Impact factor: 3.147

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Authors:  Ahmet Dirican; Betul Bolat Kucukzeybek; Ahmet Alacacioglu; Yuksel Kucukzeybek; Cigdem Erten; Umut Varol; Isil Somali; Lutfiye Demir; Ibrahim Vedat Bayoglu; Yasar Yildiz; Murat Akyol; Betul Koyuncu; Eyup Coban; Eda Ulger; Fulya Cakalagaoglu Unay; Mustafa Oktay Tarhan
Journal:  Int J Clin Oncol       Date:  2014-02-18       Impact factor: 3.402

10.  The activation pattern of blood leukocytes in head and neck squamous cell carcinoma is correlated to survival.

Authors:  Camilla Rydberg Millrud; Anne Månsson Kvarnhammar; Rolf Uddman; Sven Björnsson; Kristian Riesbeck; Lars Olaf Cardell
Journal:  PLoS One       Date:  2012-12-10       Impact factor: 3.240
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  17 in total

1.  Molecular immuno-imaging improves tumor detection in head and neck cancer.

Authors:  Jing-Hui Li; Reza Forghani; Lionel Bure; Gregory R Wojtkiewicz; Yue Wu; Yoshiko Iwamoto; Muhammad Ali; Anning Li; Cuihua Wang; Negin Jalali Motlagh; Andreas I Papadakis; Marc P Pusztaszeri; Alan Spatz; Hugh Curtin; Ying-Sheng Cheng; John W Chen
Journal:  FASEB J       Date:  2022-01       Impact factor: 5.834

2.  The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma.

Authors:  Medine Kara; Sema Uysal; Uğur Altinişik; Sibel Cevizci; Oğuz Güçlü; Fevzi Sefa Dereköy
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-08-12       Impact factor: 2.503

3.  DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes.

Authors:  Devin C Koestler; Joseph Usset; Brock C Christensen; Carmen J Marsit; Margaret R Karagas; Karl T Kelsey; John K Wiencke
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-12-13       Impact factor: 4.254

4.  Efficacy of the Evaluation of Inflammatory Markers for the Reduction of Negative Appendectomy Rates.

Authors:  Fatih Mehmet Yazar; Aykut Urfalioglu; Murat Bakacak; Ömer Faruk Boran; Ertan Bülbüloğlu
Journal:  Indian J Surg       Date:  2016-10-18       Impact factor: 0.656

5.  Pretreatment neutrophil to lymphocyte ratio in determining the prognosis of head and neck cancer: a meta-analysis.

Authors:  Yalian Yu; Hongbo Wang; Aihui Yan; Hailong Wang; Xinyao Li; Jiangtao Liu; Wei Li
Journal:  BMC Cancer       Date:  2018-04-04       Impact factor: 4.430

6.  Prognosis of neutrophil-to-lymphocyte ratio in clinical early-stage tongue (cT1/T2N0) cancer.

Authors:  Ching-Nung Wu; Hui-Ching Chuang; Yu-Tsai Lin; Fu-Min Fang; Shau-Hsuan Li; Chih-Yen Chien
Journal:  Onco Targets Ther       Date:  2017-08-04       Impact factor: 4.147

7.  Impact of hematological inflammatory markers on clinical outcome in patients with salivary duct carcinoma: a multi-institutional study in Japan.

Authors:  Daisuke Kawakita; Yuichiro Tada; Yorihisa Imanishi; Shintaro Beppu; Kiyoaki Tsukahara; Satoshi Kano; Hiroyuki Ozawa; Kenji Okami; Yuichiro Sato; Akira Shimizu; Yukiko Sato; Chihiro Fushimi; Soichiro Takase; Takuro Okada; Hiroki Sato; Kuninori Otsuka; Yoshihiro Watanabe; Akihiro Sakai; Koji Ebisumoto; Takafumi Togashi; Yushi Ueki; Hisayuki Ota; Tomotaka Shimura; Toyoyuki Hanazawa; Shingo Murakami; Toshitaka Nagao
Journal:  Oncotarget       Date:  2017-01-03

8.  Optimal cut-off for neutrophil-to-lymphocyte ratio: Fact or Fantasy? A prospective cohort study in metastatic cancer patients.

Authors:  Yann-Alexandre Vano; Stéphane Oudard; Marie-Agnès By; Pauline Têtu; Constance Thibault; Hail Aboudagga; Florian Scotté; Reza Elaidi
Journal:  PLoS One       Date:  2018-04-06       Impact factor: 3.240

9.  Survival impact of pre-treatment neutrophils on oropharyngeal and laryngeal cancer patients undergoing definitive radiotherapy.

Authors:  Whitney A Sumner; William A Stokes; Ayman Oweida; Kiersten L Berggren; Jessica D McDermott; David Raben; Diana Abbott; Bernard Jones; Gregory Gan; Sana D Karam
Journal:  J Transl Med       Date:  2017-08-02       Impact factor: 5.531

10.  Neutrophil-lymphocyte ratio complements volumetric staging as prognostic factor in patients treated with definitive radiotherapy for oropharyngeal cancer.

Authors:  Cédric Panje; Oliver Riesterer; Christoph Glanzmann; Gabriela Studer
Journal:  BMC Cancer       Date:  2017-09-11       Impact factor: 4.430
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