Literature DB >> 12361235

Amidinobenzisothiazole derivatives with antidegenerative activity on cartilage.

Annamaria Panico1, Paola Vicini, Matteo Incerti, Venera Cardile, Barbara Gentile, Giuseppe Ronsisvalle.   

Abstract

N-(Benzo[d]isothiazol-3-yl)amidines were synthesised and evaluated for their antiinflammatory activity. Encouraging results led us to evaluate these derivatives on the prevention of cartilage destruction in articular disease. Antidegenerative activity was assayed on culture of porcine nasal cartilage and diarthroidal joint human cartilage in the presence of interleukin-1beta (IL-1beta). The amount of glycosaminoglycans (GAGs) and the production of nitric oxide (NO) in the culture medium were determined. The obtained results showed that all the compounds, in the presence of IL-beta, blocked the cartilage breakdown, with different behaviour. The antidegenerative activity is more evident in human cartilage.

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Year:  2002        PMID： 12361235     DOI： 10.1016/s0014-827x(02)01231-4

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  6 in total

1.  Protective effects of benzisothiazolylamidines on IL-1 beta induced alterations in human articular chondrocyte metabolism.

Authors:  A M Panico; P Vicini; G Massimo; V Cardile; B Gentile; S Avondo; F Vittorio; G Ronsisvalle
Journal:  Inflammation       Date:  2004-08       Impact factor: 4.092

2.  Synthesis of tert-butyl (substituted benzamido)phenylcarbamate derivatives: anti-inflammatory activity and docking studies.

Authors:  Shankar Bhookya; Jalapathi Pochampally; Anil Valeru; Vianala Sunitha; Saikrishna Balabadra; Vijjulatha Manga; Karunakar Rao Kudle
Journal:  J Chem Biol       Date:  2017-04-05

3.  Synthesis, structure, and biological activity of novel heterocyclic sulfonyl-carboximidamides.

Authors:  Katarzyna Gobis; Henryk Foks; Jarosław Sławiński; Artur Sikorski; Damian Trzybiński; Ewa Augustynowicz-Kopeć; Agnieszka Napiórkowska; Krzysztof Bojanowski
Journal:  Monatsh Chem       Date:  2013-01-25       Impact factor: 1.451

4.  Synthesis, structure, and antimicrobial activity of heterocyclic phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides.

Authors:  Katarzyna Gobis; Henryk Foks; Katarzyna Wiśniewska; Maria Dąbrowska-Szponar; Ewa Augustynowicz-Kopeć; Agnieszka Napiórkowska; Artur Sikorski
Journal:  Monatsh Chem       Date:  2012-05-15       Impact factor: 1.451

5.  Mass spectrometry and theoretical studies on N-C bond cleavages in the N-sulfonylamidino thymine derivatives.

Authors:  Renata Kobetić; Snježana Kazazić; Borislav Kovačević; Zoran Glasovac; Luka Krstulović; Miroslav Bajić; Biserka Žinić
Journal:  J Am Soc Mass Spectrom       Date:  2015-03-12       Impact factor: 3.109

6.  4-Thiazolidinone Derivatives as MMP Inhibitors in Tissue Damage: Synthesis, Biological Evaluation and Docking Studies.

Authors:  Matteo Incerti; Lucia Crascì; Paola Vicini; Esin Aki; Ismail Yalcin; Tugba Ertan-Bolelli; Venera Cardile; Adriana Carol Eleonora Graziano; Annamaria Panico
Journal:  Molecules       Date:  2018-02-14       Impact factor: 4.411
  6 in total

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