Qunying Lin1, Lei Xue2, Tian Tian3, Bo Zhang3,4, Lijing Guo1, Guosheng Lin1, Zhiwei Chen1, Kexing Fan3,4, Xiaobin Gu3. 1. Department of Respiratory Medicine, Affiliated Hospital of Putian University, Putian, Fujian - China. 2. Department of Thoracic Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai - China. 3. Cancer Center, Chinese PLA General Hospital and Chinese PLA Medical School, Beijing - China. 4. International Joint Cancer Institute, The Second Military Medical University, Shanghai - China.
Abstract
OBJECTIVE: To explore the prognostic value of serum interleukin-17 (IL-17) and vascular endothelial growth factor (VEGF) levels in patients with small cell lung cancer (SCLC). MATERIALS AND METHODS: IL-17 and VEGF levels were determined by a commercially available ELISA method. RESULTS: Serum IL-17 and VEGF levels were higher in the SCLC group than the control group (p<0.001 and p<0.0001, respectively). In addition, there was a significant correlation between IL-17 and VEGF. The level of IL-17 showed significant correlations with tumor stage and tumor metastasis, while serum VEGF levels were significantly associated only with tumor metastasis. Univariate and multivariate analysis indicated that an elevated IL-17 level was an independent prognostic factor for shorter overall survival in SCLC. CONCLUSIONS: IL-17 may play an important role in tumor dissemination in SCLC patients and measurement of IL-17 could have useful prognostic value for worse overall survival in patients with SCLC.
OBJECTIVE: To explore the prognostic value of serum interleukin-17 (IL-17) and vascular endothelial growth factor (VEGF) levels in patients with small cell lung cancer (SCLC). MATERIALS AND METHODS:IL-17 and VEGF levels were determined by a commercially available ELISA method. RESULTS: Serum IL-17 and VEGF levels were higher in the SCLC group than the control group (p&lt;0.001 and p&lt;0.0001, respectively). In addition, there was a significant correlation between IL-17 and VEGF. The level of IL-17 showed significant correlations with tumor stage and tumor metastasis, while serum VEGF levels were significantly associated only with tumor metastasis. Univariate and multivariate analysis indicated that an elevated IL-17 level was an independent prognostic factor for shorter overall survival in SCLC. CONCLUSIONS:IL-17 may play an important role in tumor dissemination in SCLCpatients and measurement of IL-17 could have useful prognostic value for worse overall survival in patients with SCLC.