Literature DB >> 26164453

Biochemical protective effect of 1,25-dihydroxyvitamin D3 through autophagy induction in the MPTP mouse model of Parkinson's disease.

Huan Li1, Wooyoung Jang, Hee Ju Kim, Kwang Deog Jo, Moon Kyu Lee, Sun Hong Song, Hyun Ok Yang.   

Abstract

In our previous study, the neuroprotective effect of calcitriol was confirmed in SH-SY5Y cells. In this article, we explored whether calcitriol showed neuroprotection in a subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson's disease. After mice were treated with MPTP alone or cotreated with MPTP and calcitriol, the substantia nigra pars compacta was dissected, and related protein levels were detected by western blot. Our results suggest that the MPTP-injected mice treated with calcitriol had attenuated tyrosine hydroxylase expression and increased LC3-II conversion compared with those that were not. Above all, calcitriol showed neuroprotection in the MPTP mouse model.
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.

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Year:  2015        PMID： 26164453     DOI： 10.1097/WNR.0000000000000401

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  7 in total

Review 1.  Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.

Authors:  Barry Boland; Wai Haung Yu; Olga Corti; Bertrand Mollereau; Alexandre Henriques; Erwan Bezard; Greg M Pastores; David C Rubinsztein; Ralph A Nixon; Michael R Duchen; Giovanna R Mallucci; Guido Kroemer; Beth Levine; Eeva-Liisa Eskelinen; Fanny Mochel; Michael Spedding; Caroline Louis; Olivier R Martin; Mark J Millan
Journal:  Nat Rev Drug Discov       Date:  2018-08-17       Impact factor: 84.694

2.  Effects of calcitriol on experimental spinal cord injury in rats.

Authors:  K-L Zhou; D-H Chen; H-M Jin; K Wu; X-Y Wang; H-Z Xu; X-L Zhang
Journal:  Spinal Cord       Date:  2016-01-05       Impact factor: 2.772

Review 3.  Crosstalk between sphingolipids and vitamin D3: potential role in the nervous system.

Authors:  Mercedes Garcia-Gil; Federica Pierucci; Ambra Vestri; Elisabetta Meacci
Journal:  Br J Pharmacol       Date:  2017-02-24       Impact factor: 8.739

Review 4.  Nuclear and Cytoplasmatic Players in Mitochondria-Related CNS Disorders: Chromatin Modifications and Subcellular Trafficking.

Authors:  Matteo Gasparotto; Yi-Shin Lee; Alessandra Palazzi; Marcella Vacca; Francesco Filippini
Journal:  Biomolecules       Date:  2022-04-23

5.  Assessing the Effects of Vitamin D on Neural Network Function in Patients With Parkinson's Disease by Measuring the Fraction Amplitude of Low-Frequency Fluctuation.

Authors:  Lingling Lv; Hainan Zhang; Xuling Tan; Lixia Qin; Xinke Peng; Rongrong Bai; Qile Xiao; Changlian Tan; Haiyan Liao; Weiqian Yan; Jieqiong Tan; Beisha Tang; Chunyu Wang
Journal:  Front Aging Neurosci       Date:  2021-12-20       Impact factor: 5.750

6.  Anodal transcranial direct current stimulation prevents methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity by modulating autophagy in an in vivo mouse model of Parkinson's disease.

Authors:  Sang-Bin Lee; Hee-Tae Kim; Hyun Ok Yang; Wooyoung Jang
Journal:  Sci Rep       Date:  2018-10-11       Impact factor: 4.379

Review 7.  The relationships of vitamin D, vitamin D receptor gene polymorphisms, and vitamin D supplementation with Parkinson's disease.

Authors:  Lingling Lv; Xuling Tan; Xinke Peng; Rongrong Bai; Qile Xiao; Ting Zou; Jieqiong Tan; Hainan Zhang; Chunyu Wang
Journal:  Transl Neurodegener       Date:  2020-09-01       Impact factor: 8.014
  7 in total

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