Literature DB >> 26161114

Do physicians think genomic medicine will be useful for patient care?

Sridharan Raghavan1, Jason L Vassy2.   

Abstract

Significant technological improvements over the last decade have led to a vast expansion in the understanding of the genomic architecture of human disease. However, the use of genomic information, so-called genomic medicine, in routine clinical care, has been slow in comparison to the growth in genomic discovery. The uptake of genomic technology into clinical practice will depend on physicians' perspectives of its utility in patient care. We review recent literature addressing physician attitudes regarding the usefulness and limitations of genomic testing. We conclude by proposing research areas to better understand the role physicians will play in the uptake of genomic information into clinical medicine.

Entities:  

Keywords:  clinical utility; genomic medicine; genomic testing; pharmacogenomics; physician perspectives

Year:  2014        PMID: 26161114      PMCID: PMC4494677          DOI: 10.2217/pme.14.25

Source DB:  PubMed          Journal:  Per Med        ISSN: 1741-0541            Impact factor:   2.512


  41 in total

Review 1.  Genomic medicine--an updated primer.

Authors:  W Gregory Feero; Alan E Guttmacher; Francis S Collins
Journal:  N Engl J Med       Date:  2010-05-27       Impact factor: 91.245

2.  Effect of direct-to-consumer genomewide profiling to assess disease risk.

Authors:  Cinnamon S Bloss; Nicholas J Schork; Eric J Topol
Journal:  N Engl J Med       Date:  2011-01-12       Impact factor: 91.245

3.  Academic family physicians' perception of genetic testing and integration into practice: a CERA study.

Authors:  Arch G Mainous; Sharleen P Johnson; Svetlana Chirina; Richard Baker
Journal:  Fam Med       Date:  2013-04       Impact factor: 1.756

4.  Educational needs of primary care physicians regarding direct-to-consumer genetic testing.

Authors:  Karen P Powell; Carol A Christianson; Whitney A Cogswell; Gaurav Dave; Amit Verma; Sonja Eubanks; Vincent C Henrich
Journal:  J Genet Couns       Date:  2011-12-30       Impact factor: 2.537

5.  Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling.

Authors:  Susanne B Haga; Madeline M Carrig; Julianne M O'Daniel; Lori A Orlando; Ley A Killeya-Jones; Geoffrey S Ginsburg; Alex Cho
Journal:  J Gen Intern Med       Date:  2011-02-11       Impact factor: 5.128

6.  A pharmacogenetic versus a clinical algorithm for warfarin dosing.

Authors:  Stephen E Kimmel; Benjamin French; Scott E Kasner; Julie A Johnson; Jeffrey L Anderson; Brian F Gage; Yves D Rosenberg; Charles S Eby; Rosemary A Madigan; Robert B McBane; Sherif Z Abdel-Rahman; Scott M Stevens; Steven Yale; Emile R Mohler; Margaret C Fang; Vinay Shah; Richard B Horenstein; Nita A Limdi; James A S Muldowney; Jaspal Gujral; Patrice Delafontaine; Robert J Desnick; Thomas L Ortel; Henny H Billett; Robert C Pendleton; Nancy L Geller; Jonathan L Halperin; Samuel Z Goldhaber; Michael D Caldwell; Robert M Califf; Jonas H Ellenberg
Journal:  N Engl J Med       Date:  2013-11-19       Impact factor: 91.245

7.  Primary care physicians' knowledge of and experience with pharmacogenetic testing.

Authors:  S B Haga; W Burke; G S Ginsburg; R Mills; R Agans
Journal:  Clin Genet       Date:  2012-07-03       Impact factor: 4.438

8.  Barriers for integrating personalized medicine into clinical practice: a qualitative analysis.

Authors:  Mehdi Najafzadeh; Jennifer C Davis; Pamela Joshi; Carlo Marra
Journal:  Am J Med Genet A       Date:  2013-02-26       Impact factor: 2.802

Review 9.  Effects of communicating DNA-based disease risk estimates on risk-reducing behaviours.

Authors:  Theresa M Marteau; David P French; Simon J Griffin; A T Prevost; Stephen Sutton; Clare Watkinson; Sophie Attwood; Gareth J Hollands
Journal:  Cochrane Database Syst Rev       Date:  2010-10-06

10.  Deficiency of knowledge of genetics and genetic tests among general practitioners, gynecologists, and pediatricians: a global problem.

Authors:  Marieke J H Baars; Lidewij Henneman; Leo P Ten Kate
Journal:  Genet Med       Date:  2005 Nov-Dec       Impact factor: 8.822

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  9 in total

1.  Discussing molecular testing in oncology care: Comparing patient and physician information preferences.

Authors:  Ana P M Pinheiro; Rachel H Pocock; Jeffrey M Switchenko; Margie D Dixon; Walid L Shaib; Suresh S Ramalingam; Rebecca D Pentz
Journal:  Cancer       Date:  2017-01-31       Impact factor: 6.860

2.  On the readiness of physicians for pharmacogenomics testing: an empirical assessment.

Authors:  N Amara; J Blouin-Bougie; D Bouthillier; J Simard
Journal:  Pharmacogenomics J       Date:  2017-06-13       Impact factor: 3.550

Review 3.  Physician preparedness for big genomic data: a review of genomic medicine education initiatives in the United States.

Authors:  Caryn Kseniya Rubanovich; Cynthia Cheung; Jess Mandel; Cinnamon S Bloss
Journal:  Hum Mol Genet       Date:  2018-08-01       Impact factor: 6.150

4.  Physicians' attitudes toward pharmacogenetic testing before and after pharmacogenetic education.

Authors:  Jasmine A Luzum; Matthew J Luzum
Journal:  Per Med       Date:  2016-03-01       Impact factor: 2.512

5.  Prescriber Attitudes Toward Implementation of Pharmacogenomic Testing in a Family Medicine Residency Program.

Authors:  Alyssa Gallipani; Rebecca Cope; Briann Fischetti; Sherly Abraham; Arvind Ankireddypalli
Journal:  PRiMER       Date:  2018-10-11

6.  Clinical pharmacogenomics: patient perspectives of pharmacogenomic testing and the incidence of actionable test results in a chronic disease cohort.

Authors:  Chandrama Mukherjee; Kevin M Sweet; Jasmine A Luzum; Mahmoud Abdel-Rasoul; Michael F Christman; Joseph P Kitzmiller
Journal:  Per Med       Date:  2017-09-01       Impact factor: 2.512

7.  Genomic sequencing in oncology: Considerations for integration in routine cancer care.

Authors:  Belinda Rahman; Alastair Lamb; Andrew Protheroe; Ketan Shah; Joyce Solomons; Jonathan Williams; Elizabeth Ormondroyd
Journal:  Eur J Cancer Care (Engl)       Date:  2022-04-05       Impact factor: 2.328

8.  Precision Population Medicine in Primary Care: The Sanford Chip Experience.

Authors:  Kurt D Christensen; Megan Bell; Carrie L B Zawatsky; Lauren N Galbraith; Robert C Green; Allison M Hutchinson; Leila Jamal; Jessica L LeBlanc; Jennifer R Leonhard; Michelle Moore; Lisa Mullineaux; Natasha Petry; Dylan M Platt; Sherin Shaaban; April Schultz; Bethany D Tucker; Joel Van Heukelom; Elizabeth Wheeler; Emilie S Zoltick; Catherine Hajek
Journal:  Front Genet       Date:  2021-03-12       Impact factor: 4.599

9.  Physicians' perspectives on receiving unsolicited genomic results.

Authors:  Douglas B Pet; Ingrid A Holm; Janet L Williams; Melanie F Myers; Laurie L Novak; Kyle B Brothers; Georgia L Wiesner; Ellen W Clayton
Journal:  Genet Med       Date:  2018-07-05       Impact factor: 8.822

  9 in total

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