Literature DB >> 2615851

Age-related differences in human platelet 5-HT uptake.

D Marazziti1, M F Falcone, A Rotondo, P Castrogiovanni.   

Abstract

Platelet 5-hydroxytryptamine (5-HT) uptake was measured in a group of young healthy volunteers and a group of aged healthy volunteers. Our results show a significant increase in the maximal velocity of uptake (Vmax) in the platelets of aged subjects. This could result in a decreased concentration of extracellular 5-HT in old age. Such reduced levels of 5-HT, if they occurred at 5-HT synapses in the brain, could result in susceptibility to the development of neurological or psychiatric illness.

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Year:  1989        PMID： 2615851     DOI： 10.1007/bf00260616

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  9 in total

1.  Age-related changes in 5HT uptake and [3H]imipramine binding sites in rat cerebral cortex.

Authors:  N Brunello; M Riva; A Volterra; G Racagni
Journal:  Eur J Pharmacol       Date:  1985-04-16       Impact factor: 4.432

Review 2.  Blood platelets as a model for monoamine-containing neurones.

Authors:  J M Sneddon
Journal:  Prog Neurobiol       Date:  1973       Impact factor: 11.685

3.  A modified assay method for determining serotonin uptake in human platelets.

Authors:  R C Arora; H Y Meltzer
Journal:  Clin Chim Acta       Date:  1981-05-05       Impact factor: 3.786

4.  Imipramine receptors in human platelets: effect of age.

Authors:  D Marazziti; P Giusti; A Rotondo; G F Placidi; G M Pacifici
Journal:  Int J Clin Pharmacol Res       Date:  1987

5.  Purification and properties of a human plasma endogenous modulator for the platelet tricyclic binding/serotonin transport complex.

Authors:  K I Abraham; J R Ieni; L R Meyerson
Journal:  Biochim Biophys Acta       Date:  1987-01-20

6.  Elevated density of [3H]imipramine binding in aged human brain.

Authors:  J A Severson; J O Marcusson; H H Osterburg; C E Finch; B Winblad
Journal:  J Neurochem       Date:  1985-11       Impact factor: 5.372

7.  Involvement of hippocampal serotonergic activity in age-related changes in exploratory behavior.

Authors:  M J Brennan; A Dallob; E Friedman
Journal:  Neurobiol Aging       Date:  1981       Impact factor: 4.673

8.  Specific 3H-imipramine binding in human platelets. Influence of age and sex.

Authors:  S Z Langer; M S Briley; R Raisman; J F Henry; P L Morselli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-09       Impact factor: 3.000

9.  Allosteric interaction between the site labeled by [3H]imipramine and the serotonin transporter in human platelets.

Authors:  L R Meyerson; J R Ieni; L P Wennogle
Journal:  J Neurochem       Date:  1987-02       Impact factor: 5.372
  9 in total
  1 in total

1.  Platelet serotonin uptake sites increased in drinkers of ayahuasca.

Authors:  J C Callaway; M M Airaksinen; D J McKenna; G S Brito; C S Grob
Journal:  Psychopharmacology (Berl)       Date:  1994-11       Impact factor: 4.530
  1 in total

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