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Literature DB >> 26156325

Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker.

Shuo Zeng¹, Yu-Feng Xiao¹, Bo Tang¹, Chang-Jiang Hu¹, Rei Xie¹, Shi-Ming Yang¹, Bo-Sheng Li².

Abstract

Digestive tract cancers (DTCs) are a leading cause of cancer-related death worldwide. Current therapeutic tools for advanced stage DTCs have limitations, and patients with early stage DTCs frequently have a missed diagnosis due to shortage of efficient biomarkers. Consequently, it is necessary to develop novel biomarkers for early diagnosis and novel therapeutic targets for treatment of DTCs. In recent years, long noncoding RNAs (lncRNAs), a class of noncoding RNAs with >200 nucleotides, have been shown to be aberrantly expressed in DTCs and to have an important role in DTC development: the expression profiles of lncRNAs strongly correlated with poor survival of patients with DTCs, and lncRNAs acted as oncogenes or tumor suppressor genes in DTC progression. In this review, we summarized the functional lncRNAs and expounded on their regulatory mechanisms in DTCs. ©AlphaMed Press.

Entities: Disease Species

Keywords: Biomarker; Digestive tract cancers; Epigenetic regulation; Long noncoding RNAs

Mesh：

Substances：

Year: 2015 PMID： 26156325 PMCID： PMC4524753 DOI： 10.1634/theoncologist.2014-0475

Source DB: PubMed Journal: Oncologist ISSN： 1083-7159

88 in total

1. SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer.

Authors: T-P Xu; X-X Liu; R Xia; L Yin; R Kong; W-M Chen; M-D Huang; Y-Q Shu
Journal: Oncogene Date: 2015-03-02 Impact factor: 9.867

Review 2. Evolution and functions of long noncoding RNAs.

Authors: Chris P Ponting; Peter L Oliver; Wolf Reik
Journal: Cell Date: 2009-02-20 Impact factor: 41.582

3. Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome.

Authors: Jeannie T Lee
Journal: Genes Dev Date: 2009-08-15 Impact factor: 11.361

4. The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells.

Authors: Chuanhui Cao; Jingyuan Sun; Dongyan Zhang; Xuejun Guo; Liwei Xie; Xin Li; Dehua Wu; Li Liu
Journal: Gastroenterology Date: 2014-10-22 Impact factor: 22.682

5. Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence.

Authors: A R Glover; J T Zhao; J C Ip; J C Lee; B G Robinson; A J Gill; P S H Soon; S B Sidhu
Journal: Endocr Relat Cancer Date: 2015-02 Impact factor: 5.678

6. Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205.

Authors: Hiroshi Hirata; Yuji Hinoda; Varahram Shahryari; Guoren Deng; Koichi Nakajima; Z Laura Tabatabai; Nobuhisa Ishii; Rajvir Dahiya
Journal: Cancer Res Date: 2015-01-19 Impact factor: 12.701

7. A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis.

Authors: Bodu Liu; Lijuan Sun; Qiang Liu; Chang Gong; Yandan Yao; Xiaobin Lv; Ling Lin; Herui Yao; Fengxi Su; Dangsheng Li; Musheng Zeng; Erwei Song
Journal: Cancer Cell Date: 2015-03-09 Impact factor: 31.743

8. Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2.

Authors: L Han; E-b Zhang; D-d Yin; R Kong; T-p Xu; W-m Chen; R Xia; Y-q Shu; W De
Journal: Cell Death Dis Date: 2015-02-26 Impact factor: 8.469

9. Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.

Authors: Xiangting Wang; Shigeki Arai; Xiaoyuan Song; Donna Reichart; Kun Du; Gabriel Pascual; Paul Tempst; Michael G Rosenfeld; Christopher K Glass; Riki Kurokawa
Journal: Nature Date: 2008-05-28 Impact factor: 49.962

10. A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis.

Authors: Seong-Min Park; Sung-Joon Park; Hee-Jin Kim; Oh-Hyung Kwon; Tae-Wook Kang; Hyun-Ahm Sohn; Seon-Kyu Kim; Seung Moo Noh; Kyu-Sang Song; Se-Jin Jang; Yong Sung Kim; Seon-Young Kim
Journal: Exp Mol Med Date: 2013-07-12 Impact factor: 8.718

20 in total

1. Elevated HOTAIR expression associated with cisplatin resistance in non-small cell lung cancer patients.

Authors: Ming-Yue Liu; Xi-Qing Li; Tian-Hui Gao; Yao Cui; Ning Ma; Yun Zhou; Guo-Jun Zhang
Journal: J Thorac Dis Date: 2016-11 Impact factor: 2.895

2. Long non-coding RNA AFAP1-antisense RNA 1 promotes the proliferation, migration and invasion of gastric cancer cells and is associated with poor patient survival.

Authors: Huazhou Zhao; Kecheng Zhang; Ting Wang; Jianxin Cui; Hongqing Xi; Yi Wang; Yanjing Song; Xudong Zhao; Bo Wei; Lin Chen
Journal: Oncol Lett Date: 2018-03-30 Impact factor: 2.967

3. Long non-coding RNA ZEB2-AS1 regulates osteosarcoma progression by acting as a molecular sponge of miR-107 to modulate SALL4 expression.

Authors: Yu Wang; Ning Liu; Ming-Yue Li; Mao-Fang Du
Journal: Am J Transl Res Date: 2021-03-15 Impact factor: 4.060

Long Noncoding RNA in Digestive Tract Cancers: Function, Mechanism, and Potential Biomarker.

1. SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer.

Review 2. Evolution and functions of long noncoding RNAs.

3. Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome.

4. The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells.

5. Long noncoding RNA profiles of adrenocortical cancer can be used to predict recurrence.

6. Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205.

7. A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis.

8. Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2.

9. Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.

10. A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis.

1. Elevated HOTAIR expression associated with cisplatin resistance in non-small cell lung cancer patients.

2. Long non-coding RNA AFAP1-antisense RNA 1 promotes the proliferation, migration and invasion of gastric cancer cells and is associated with poor patient survival.

3. Long non-coding RNA ZEB2-AS1 regulates osteosarcoma progression by acting as a molecular sponge of miR-107 to modulate SALL4 expression.

4. The long non-coding RNA UPAT promotes gastric cancer cell progression via UHRF1.

Review 5. Long Noncoding RNAs in Gastrointestinal Cancer: Tumor Suppression Versus Tumor Promotion.

Review 6. The involvement of lncRNAs in the development and progression of pancreatic cancer.

Review 7. Long non-coding RNA regulation of epithelial-mesenchymal transition in cancer metastasis.

Review 8. Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma.

9. Delphinidin-3-glucoside suppresses breast carcinogenesis by inactivating the Akt/HOTAIR signaling pathway.

10. Analysis of long non-coding RNA expression profiles in pancreatic ductal adenocarcinoma.