Literature DB >> 26156292

Optimized quinoline amino alcohols as disruptors and dispersal agents of Vibrio cholerae biofilms.

Brian León1, F P Jake Haeckl, Roger G Linington.   

Abstract

The biofilm state is an integral part of the lifecycle of many bacterial pathogens. Identifying inhibitors as molecular probes against bacterial biofilms has numerous potential biomedical applications. Here we report quinoline amino alcohol as a highly potent disruptor of V. cholerae biofilms. Additionally, was able to disperse preformed biofilms, an activity exhibited by few compounds with biofilm inhibiting activity.

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Year:  2015        PMID： 26156292      PMCID： PMC4521388          DOI： 10.1039/c5ob01134e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  20 in total

1.  "Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening.

Authors:  Christopher J Schulze; Walter M Bray; Marcos H Woerhmann; Joshua Stuart; R Scott Lokey; Roger G Linington
Journal:  Chem Biol       Date:  2013-02-21

2.  From Racemates to Single Enantiomers - Chiral Synthetic Drugs over the last 20 Years.

Authors:  Hisamichi Murakami
Journal:  Top Curr Chem       Date:  2007

Review 3.  Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era.

Authors:  Maria Kostakioti; Maria Hadjifrangiskou; Scott J Hultgren
Journal:  Cold Spring Harb Perspect Med       Date:  2013-04-01       Impact factor: 6.915

4.  Synthesis of Diaryliodonium Salts Having Pentafluorosulfanylarenes and Their Application to Electrophilic Pentafluorosulfanylarylation of C-, O-, N-, and S-Nucleophiles.

Authors:  Kohei Matsuzaki; Kenta Okuyama; Etsuko Tokunaga; Norimichi Saito; Motoo Shiro; Norio Shibata
Journal:  Org Lett       Date:  2015-05-29       Impact factor: 6.005

5.  Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.

Authors:  Jose M Coteron; María Marco; Jorge Esquivias; Xiaoyi Deng; Karen L White; John White; Maria Koltun; Farah El Mazouni; Sreekanth Kokkonda; Kasiram Katneni; Ravi Bhamidipati; David M Shackleford; Iñigo Angulo-Barturen; Santiago B Ferrer; María Belén Jiménez-Díaz; Francisco-Javier Gamo; Elizabeth J Goldsmith; William N Charman; Ian Bathurst; David Floyd; David Matthews; Jeremy N Burrows; Pradipsinh K Rathod; Susan A Charman; Margaret A Phillips
Journal:  J Med Chem       Date:  2011-07-14       Impact factor: 7.446

6.  RETRACTED: Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.

Authors:  Satish Srinivas Kitambi; Enrique M Toledo; Dmitry Usoskin; Shimei Wee; Aditya Harisankar; Richard Svensson; Kristmundur Sigmundsson; Christina Kalderén; Mia Niklasson; Soumi Kundu; Sergi Aranda; Bengt Westermark; Lene Uhrbom; Michael Andäng; Peter Damberg; Sven Nelander; Ernest Arenas; Per Artursson; Julian Walfridsson; Karin Forsberg Nilsson; Lars G J Hammarström; Patrik Ernfors
Journal:  Cell       Date:  2014-03-20       Impact factor: 41.582

7.  Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.

Authors:  Peter Wipf; Tingting Mo; Steven J Geib; Diana Caridha; Geoffrey S Dow; Lucia Gerena; Norma Roncal; Erin E Milner
Journal:  Org Biomol Chem       Date:  2009-08-07       Impact factor: 3.876

8.  Molecular architecture and assembly principles of Vibrio cholerae biofilms.

Authors:  Veysel Berk; Jiunn C N Fong; Graham T Dempsey; Omer N Develioglu; Xiaowei Zhuang; Jan Liphardt; Fitnat H Yildiz; Steven Chu
Journal:  Science       Date:  2012-07-13       Impact factor: 47.728

9.  Multistate point-prevalence survey of health care-associated infections.

Authors:  Shelley S Magill; Jonathan R Edwards; Wendy Bamberg; Zintars G Beldavs; Ghinwa Dumyati; Marion A Kainer; Ruth Lynfield; Meghan Maloney; Laura McAllister-Hollod; Joelle Nadle; Susan M Ray; Deborah L Thompson; Lucy E Wilson; Scott K Fridkin
Journal:  N Engl J Med       Date:  2014-03-27       Impact factor: 91.245

10.  Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae.

Authors:  Christopher J A Warner; Andrew T Cheng; Fitnat H Yildiz; Roger G Linington
Journal:  Chem Commun (Camb)       Date:  2015-01-25       Impact factor: 6.222
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  1 in total

Review 1.  Strategies and Approaches for Discovery of Small Molecule Disruptors of Biofilm Physiology.

Authors:  Michael A Trebino; Rahul D Shingare; John B MacMillan; Fitnat H Yildiz
Journal:  Molecules       Date:  2021-07-29       Impact factor: 4.411
  1 in total

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