Jiang Xue1, Ai-hong Liu1, Bin Zhao2, Min Si3, Ya-qiong Li1. 1. a Department of Neonatology , The Second Affiliated Hospital of Shandong University , Jinan , People's Republic of China . 2. b Department of Padiatric Surgery , Central Hospital of Taian City , Taian , People's Republic of China , and. 3. c Department of Pediatric Intensive Care , Jinan Central Hospital affiliated Shandong University , Jinan , People's Republic of China.
Abstract
OBJECTIVE: The aim of this study was to explore the association between serum levels of mannose-binding lectin (MBL) at admission and neurodevelopmental outcomes in a group of Chinese preterm infants, observed prospectively, until 1-year of corrected age (CA). METHODS: All preterm infants used in this study were received from the neonatal intensive care unit (NICU) of our Hospital between 1 January 2012 and 31 August 2013. Serum levels of MBL and clinical data were obtained at the time of admission. The influence of MBL levels on neurological outcome was assessed by logistic regression analysis. Clinical follow-up was performed at 1 year. RESULTS: The study cohort consisted of 175 neonates at baseline and 105 finished the 1-year follow-up. The mean serum MBL levels at the time of admission were significantly lower in children with adverse neurological outcomes as compared with children with no adverse [0.53 (SD = 0.09) μg/ml versus 0.80 (SD = 0.17) μg/ml, respectively; t = 8.342, p < 0.0001]. In multivariate analysis, there was an increased risk of adverse neurological outcomes associated with MBL ≤ 0.68 μg/ml [odds ratios (OR) = 12.11, 95% confidence interval (CI): 2.31-30.32; p < 0.0001] after adjusting for possible factors. CONCLUSION: Preterm infants who had low levels of MBL at admission are exposed to an increased risk of adverse neurological outcomes.
OBJECTIVE: The aim of this study was to explore the association between serum levels of mannose-binding lectin (MBL) at admission and neurodevelopmental outcomes in a group of Chinese preterm infants, observed prospectively, until 1-year of corrected age (CA). METHODS: All preterm infants used in this study were received from the neonatal intensive care unit (NICU) of our Hospital between 1 January 2012 and 31 August 2013. Serum levels of MBL and clinical data were obtained at the time of admission. The influence of MBL levels on neurological outcome was assessed by logistic regression analysis. Clinical follow-up was performed at 1 year. RESULTS: The study cohort consisted of 175 neonates at baseline and 105 finished the 1-year follow-up. The mean serum MBL levels at the time of admission were significantly lower in children with adverse neurological outcomes as compared with children with no adverse [0.53 (SD = 0.09) μg/ml versus 0.80 (SD = 0.17) μg/ml, respectively; t = 8.342, p < 0.0001]. In multivariate analysis, there was an increased risk of adverse neurological outcomes associated with MBL ≤ 0.68 μg/ml [odds ratios (OR) = 12.11, 95% confidence interval (CI): 2.31-30.32; p < 0.0001] after adjusting for possible factors. CONCLUSION: Preterm infants who had low levels of MBL at admission are exposed to an increased risk of adverse neurological outcomes.
Authors: Daniel Seung Kim; Yatong K Li; Jerry H Kim; Curtis S Bergquist; Marsha Gerdes; Judy C Bernbaum; Nancy Burnham; Donna M McDonald-McGinn; Elaine H Zackai; Susan C Nicolson; Thomas L Spray; Deborah A Nickerson; Hakon Hakonarson; Gail P Jarvik; J William Gaynor Journal: J Thorac Cardiovasc Surg Date: 2017-12-07 Impact factor: 5.209