BACKGROUND: Arteriosclerosis is a pathological, structural (media vascular calcification) and physiological (modified vascular smooth vessel cells; increased arterial stiffness) alteration of the vessel wall. Through improved assessment methods (functional and imaging), it has become a well-known phenomenon in recent decades. However, its clinical importance was underestimated until recently. MATERIALS AND METHODS: Currently available English-speaking data about conditions/diseases associated with arteriosclerosis, its clinical sequels, available diagnostic procedures and therapeutic modalities were reviewed and summarized. RESULTS: In recent decades, emerging data have brought about a better understanding of causes and consequences of arteriosclerosis and highlight its growing clinical impact. CONCLUSION: Although arteriosclerosis showed an independent clinical impact on cardiovascular morbidity and mortality, especially in patients with chronic kidney disease/end-stage renal disease (CKD/ESRD) and diabetes mellitus, convincing clinical therapy concepts are not available until now. The establishment of novel therapeutic strategies derived from basic research is strongly needed.
BACKGROUND:Arteriosclerosis is a pathological, structural (media vascular calcification) and physiological (modified vascular smooth vessel cells; increased arterial stiffness) alteration of the vessel wall. Through improved assessment methods (functional and imaging), it has become a well-known phenomenon in recent decades. However, its clinical importance was underestimated until recently. MATERIALS AND METHODS: Currently available English-speaking data about conditions/diseases associated with arteriosclerosis, its clinical sequels, available diagnostic procedures and therapeutic modalities were reviewed and summarized. RESULTS: In recent decades, emerging data have brought about a better understanding of causes and consequences of arteriosclerosis and highlight its growing clinical impact. CONCLUSION: Although arteriosclerosis showed an independent clinical impact on cardiovascular morbidity and mortality, especially in patients with chronic kidney disease/end-stage renal disease (CKD/ESRD) and diabetes mellitus, convincing clinical therapy concepts are not available until now. The establishment of novel therapeutic strategies derived from basic research is strongly needed.
Authors: Joshua R Lewis; John T Schousboe; Wai H Lim; Germaine Wong; Kun Zhu; Ee M Lim; Kevin E Wilson; Peter L Thompson; Douglas P Kiel; Richard L Prince Journal: Arterioscler Thromb Vasc Biol Date: 2015-11-24 Impact factor: 8.311
Authors: Britt Opdebeeck; Ellen Neven; José Luis Millán; Anthony B Pinkerton; Patrick C D'Haese; Anja Verhulst Journal: Bone Date: 2020-04-30 Impact factor: 4.398
Authors: M P M Graham-Brown; D S March; D R Churchward; H M L Young; M Dungey; S Lloyd; N J Brunskill; A C Smith; G P McCann; J O Burton Journal: BMC Nephrol Date: 2016-07-08 Impact factor: 2.388