Literature DB >> 28696417

Harnessing low-density lipoprotein receptor protein 6 (LRP6) genetic variation and Wnt signaling for innovative diagnostics in complex diseases.

Z-M Wang1,2, J-Q Luo1,2, L-Y Xu3, H-H Zhou1,2, W Zhang1,2.   

Abstract

Wnt signaling regulates a broad variety of processes in both embryonic development and various diseases. Recent studies indicated that some genetic variants in Wnt signaling pathway may serve as predictors of diseases. Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to many complex human diseases, including metabolic syndrome, cancer, Alzheimer's disease and osteoporosis. Therefore, we focus on the role of LRP6 genetic polymorphisms and Wnt signaling in complex diseases, and the mechanisms from mouse models and cell lines. It is also highly anticipated that LRP6 variants will be applied clinically in the future. The brief review provided here could be a useful resource for future research and may contribute to a more accurate diagnosis in complex diseases.

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Year:  2017        PMID： 28696417     DOI： 10.1038/tpj.2017.28

Source DB:  PubMed          Journal:  Pharmacogenomics J        ISSN： 1470-269X            Impact factor:   3.550


  80 in total

1.  Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes.

Authors:  Anne-Marie Sims; Neil Shephard; Kim Carter; Tracy Doan; Alison Dowling; Emma L Duncan; John Eisman; Graeme Jones; Geoffrey Nicholson; Richard Prince; Ego Seeman; Gethin Thomas; John A Wass; Matthew A Brown
Journal:  J Bone Miner Res       Date:  2008-04       Impact factor: 6.741

2.  Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism.

Authors:  Julia Steinberger; Stephen R Daniels; Robert H Eckel; Laura Hayman; Robert H Lustig; Brian McCrindle; Michele L Mietus-Snyder
Journal:  Circulation       Date:  2009-01-12       Impact factor: 29.690

3.  Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.

Authors:  Zhihong Cheng; Travis Biechele; Zhiyi Wei; Seamus Morrone; Randall T Moon; Liguo Wang; Wenqing Xu
Journal:  Nat Struct Mol Biol       Date:  2011-10-09       Impact factor: 15.369

4.  LRP6 mutation in a family with early coronary disease and metabolic risk factors.

Authors:  Arya Mani; Jayaram Radhakrishnan; He Wang; Alaleh Mani; Mohammad-Ali Mani; Carol Nelson-Williams; Khary S Carew; Shrikant Mane; Hossein Najmabadi; Dan Wu; Richard P Lifton
Journal:  Science       Date:  2007-03-02       Impact factor: 47.728

5.  The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.

Authors:  Olivia G Kelly; Kathy I Pinson; William C Skarnes
Journal:  Development       Date:  2004-05-13       Impact factor: 6.868

6.  Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis.

Authors:  Chikara Kokubu; Ulrich Heinzmann; Tomoko Kokubu; Norio Sakai; Takuo Kubota; Masanobu Kawai; Matthias B Wahl; Juan Galceran; Rudolf Grosschedl; Keiichi Ozono; Kenji Imai
Journal:  Development       Date:  2004-10-06       Impact factor: 6.868

Review 7.  Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism.

Authors:  Stavros C Manolagas; Maria Almeida
Journal:  Mol Endocrinol       Date:  2007-07-10

8.  Control of bone formation by the serpentine receptor Frizzled-9.

Authors:  Joachim Albers; Jochen Schulze; F Timo Beil; Matthias Gebauer; Anke Baranowsky; Johannes Keller; Robert P Marshall; Kristofer Wintges; Felix W Friedrich; Matthias Priemel; Arndt F Schilling; Johannes M Rueger; Kerstin Cornils; Boris Fehse; Thomas Streichert; Guido Sauter; Franz Jakob; Karl L Insogna; Barbara Pober; Klaus-Peter Knobeloch; Uta Francke; Michael Amling; Thorsten Schinke
Journal:  J Cell Biol       Date:  2011-03-14       Impact factor: 10.539

9.  Wnt signaling pathway pharmacogenetics in non-small cell lung cancer.

Authors:  D J Stewart; D W Chang; Y Ye; M Spitz; C Lu; X Shu; J A Wampfler; R S Marks; Y I Garces; P Yang; X Wu
Journal:  Pharmacogenomics J       Date:  2014-07-01       Impact factor: 3.550

10.  Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.

Authors:  Giancarlo V De Ferrari; Andreas Papassotiropoulos; Travis Biechele; Fabienne Wavrant De-Vrieze; Miguel E Avila; Michael B Major; Amanda Myers; Katia Sáez; Juan P Henríquez; Alice Zhao; M Axel Wollmer; Roger M Nitsch; Christoph Hock; Chris M Morris; John Hardy; Randall T Moon
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-21       Impact factor: 11.205
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  7 in total

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Authors:  秋丽 曹; 小炜 黎; 秀萍 禤; 松 黄; 雪梅 谢
Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban       Date:  2021-12-25

2.  Changes of LRP6/β-catenin pathway in adipose tissue of rats with intrauterine growth restriction with catch-up growth.

Authors:  Qiuli Cao; Xiaowei Li; Xiuping Xuan; Song Huang; Xuemei Xie
Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban       Date:  2021-12-25

3.  LRP6-CRISPR prevents activation of hepatic stellate cells and liver fibrogenesis in rats.

Authors:  Linghua Yu; Linlin Wang; Huixing Yi; Xiaojun Wu
Journal:  Am J Transl Res       Date:  2020-02-15       Impact factor: 4.060

4.  The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.

Authors:  Edna Grünblatt; Zsofia Nemoda; Anna Maria Werling; Alexander Roth; Nora Angyal; Zsanett Tarnok; Hauke Thomsen; Triinu Peters; Anke Hinney; Johannes Hebebrand; Klaus-Peter Lesch; Marcel Romanos; Susanne Walitza
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2018-11-25       Impact factor: 3.568

5.  IUGR with catch-up growth programs impaired insulin sensitivity through LRP6/IRS-1 in male rats.

Authors:  Wenjun Long; Tuo Zhou; Xiuping Xuan; Qiuli Cao; Zuojie Luo; Yingfen Qin; Qin Ning; Xiaoping Luo; Xuemei Xie
Journal:  Endocr Connect       Date:  2022-01-10       Impact factor: 3.335

6.  Identification of Novel Variants in Cleft Palate-Associated Genes in Brazilian Patients With Non-syndromic Cleft Palate Only.

Authors:  Renato Assis Machado; Hercílio Martelli-Junior; Silvia Regina de Almeida Reis; Erika Calvano Küchler; Rafaela Scariot; Lucimara Teixeira das Neves; Ricardo D Coletta
Journal:  Front Cell Dev Biol       Date:  2021-07-08

Review 7.  LRP6 Receptor Plays Essential Functions in Development and Human Diseases.

Authors:  Abdulmajeed Fahad Alrefaei; Muhammad Abu-Elmagd
Journal:  Genes (Basel)       Date:  2022-01-10       Impact factor: 4.096
  7 in total

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