Samuel Sarrazin1, Marc-Antoine d'Albis1, Colm McDonald1, Julia Linke1, Michèle Wessa1, Mary Phillips1, Marine Delavest1, Louise Emsell1, Amelia Versace1, Jorge Almeida1, Jean-François Mangin1, Cyril Poupon1, Katia Le Dudal1, Claire Daban1, Nora Hamdani1, Marion Leboyer1, Josselin Houenou1. 1. From AP-HP, Hôpital H. Mondor - A. Chenevier, DHU PePSY, Pôle de Psychiatrie, Créteil, France (Sarrazin, d'Albis, Daban, Hamdani, Leboyer, Houenou); Université Paris-Est, UMR_S955, UPEC, F-94000, Créteil, France (Sarrazin, Leboyer); Fondation FondaMental, fondation de coopération scientifique, F-94000, Créteil, France (Sarrazin, d'Albis, Daban, Hamdani, Leboyer, Houenou); UNIACT, Neurospin, Commissariat à l'Energie Atomique, Centre d'études de Saclay, Gif sur Yvette (Sarrazin, d'Albis, Houenou); INSERM, U955, Equipe Psychopathologie des maladies psychiatriques, F-94000, Créteil, France (Sarrazin, d'Albis, Daban, Hamdani, Leboyer, Houenou); Clinical Science Institute, National University of Ireland, Galway, Ireland (McDonald); Institute for Psychology Johannes Gutenberg-University of Mainz, Department of Clinical Psychology and Neuropsychology, Mainz, Germany (Linke, Wessa); Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. (Phillips, Versace, Almeida); AP-HP, Hôpital Fernand Widal-Lariboisière, Service de psychiatrie, Paris, France (Delavest); Translational MRI, Department of Imaging and Pathology, KU Leuven and Radiology, University Hospitals Leuven, Belgium (Emsell); UNATI, Neurospin, Commissariat à l'Energie Atomique, Centre d'études de Saclay, Gif sur Yvette, France (Mangin); UNIRS, Neurospin, Commissariat à l'Energie Atomique, Centre d'études de Saclay, Gif sur Yvette, France (Poupon); AP-HP, Centre d'Investigation Clinique et Plateforme de Ressources Biologiques, Hôpitaux Henri Mondor, Créteil, France (Le Dudal).
Abstract
BACKGROUND: Previous studies have reported MRI abnormalities of the corpus callosum (CC) in patients with bipolar disorder (BD), although only a few studies have directly compared callosal areas in psychotic versus nonpsychotic patients with this disorder. We sought to compare regional callosal areas in a large international multicentre sample of patients with BD and healthy controls. METHODS: We analyzed anatomic T1 MRI data of patients with BD-I and healthy controls recruited from 4 sites (France, Germany, Ireland and the United States). We obtained the mid-sagittal areas of 7 CC subregions using an automatic CC delineation. Differences in regional callosal areas between patients and controls were compared using linear mixed models (adjusting for age, sex, handedness, brain volume, history of alcohol abuse/dependence, lithium or antipsychotic medication status, symptomatic status and site) and multiple comparisons correction. We also compared regional areas of the CC between patients with BD with and without a history of psychotic features. RESULTS: We included 172 patients and 146 controls in our study. Patients with BD had smaller adjusted mid-sagittal CC areas than controls along the posterior body, the isthmus and the splenium of the CC. Patients with a positive history of psychotic features had greater adjusted area of the rostral CC region than those without a history of psychotic features. LIMITATIONS: We found small to medium effect sizes, and there was no calibration technique among the sites. CONCLUSION: Our results suggest that BD with psychosis is associated with a different pattern of interhemispheric connectivity than BD without psychosis and could be considered a relevant neuroimaging subtype of BD.
BACKGROUND: Previous studies have reported MRI abnormalities of the corpus callosum (CC) in patients with bipolar disorder (BD), although only a few studies have directly compared callosal areas in psychotic versus nonpsychoticpatients with this disorder. We sought to compare regional callosal areas in a large international multicentre sample of patients with BD and healthy controls. METHODS: We analyzed anatomic T1 MRI data of patients with BD-I and healthy controls recruited from 4 sites (France, Germany, Ireland and the United States). We obtained the mid-sagittal areas of 7 CC subregions using an automatic CC delineation. Differences in regional callosal areas between patients and controls were compared using linear mixed models (adjusting for age, sex, handedness, brain volume, history of alcohol abuse/dependence, lithium or antipsychotic medication status, symptomatic status and site) and multiple comparisons correction. We also compared regional areas of the CC between patients with BD with and without a history of psychotic features. RESULTS: We included 172 patients and 146 controls in our study. Patients with BD had smaller adjusted mid-sagittal CC areas than controls along the posterior body, the isthmus and the splenium of the CC. Patients with a positive history of psychotic features had greater adjusted area of the rostral CC region than those without a history of psychotic features. LIMITATIONS: We found small to medium effect sizes, and there was no calibration technique among the sites. CONCLUSION: Our results suggest that BD with psychosis is associated with a different pattern of interhemispheric connectivity than BD without psychosis and could be considered a relevant neuroimaging subtype of BD.
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