Literature DB >> 26150642

A severe case of vasoplegic shock following metformin overdose successfully treated with methylene blue as a last line therapy.

Rachel Erin Graham1, Michaela Cartner1, James Winearls1.   

Abstract

A 44-year-old man presented to hospital 24 h after an intentional overdose of metformin and gliclazide. He had a critical metabolic acidosis on presentation with a pH of 6.88, and very rapidly deteriorated into distributive shock refractory to large volume fluid resuscitation and massive doses of vasopressors. We introduced a methylene blue infusion as a rescue therapy in an attempt to improve the patient's haemodynamics, which was successful. The patient made a full recovery with no long-term sequelae. 2015 BMJ Publishing Group Ltd.

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Year:  2015        PMID： 26150642      PMCID： PMC4493209          DOI： 10.1136/bcr-2015-210229

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  39 in total

1.  Prone positioning in severe acute respiratory distress syndrome.

Authors:  Claude Guérin; Jean Reignier; Jean-Christophe Richard; Pascal Beuret; Arnaud Gacouin; Thierry Boulain; Emmanuelle Mercier; Michel Badet; Alain Mercat; Olivier Baudin; Marc Clavel; Delphine Chatellier; Samir Jaber; Sylvène Rosselli; Jordi Mancebo; Michel Sirodot; Gilles Hilbert; Christian Bengler; Jack Richecoeur; Marc Gainnier; Frédérique Bayle; Gael Bourdin; Véronique Leray; Raphaele Girard; Loredana Baboi; Louis Ayzac
Journal:  N Engl J Med       Date:  2013-05-20       Impact factor: 91.245

2.  Local cutaneous necrosis secondary to a prolonged peripheral infusion of methylene blue in vasodilatory shock.

Authors:  Tristan Charles Dumbarton; Sean K Gorman; Samuel Minor; Osama Loubani; Fletcher White; Robert Green
Journal:  Ann Pharmacother       Date:  2012-02-28       Impact factor: 3.154

Review 3.  Vasoplegic syndrome--the role of methylene blue.

Authors:  Ganesh Shanmugam
Journal:  Eur J Cardiothorac Surg       Date:  2005-09-06       Impact factor: 4.191

4.  Blockade of the action of nitric oxide in human septic shock increases systemic vascular resistance and has detrimental effects on pulmonary function after a short infusion of methylene blue.

Authors:  R Weingartner; E Oliveira; E S Oliveira; U L Sant'Anna; R P Oliveira; L A Azambuja; G Friedman
Journal:  Braz J Med Biol Res       Date:  1999-12       Impact factor: 2.590

5.  Methylene blue in the treatment of refractory shock from an amlodipine overdose.

Authors:  David H Jang; Lewis S Nelson; Robert S Hoffman
Journal:  Ann Emerg Med       Date:  2011-05-05       Impact factor: 5.721

6.  Changes in BP induced by passive leg raising predict response to fluid loading in critically ill patients.

Authors:  Thierry Boulain; Jean-Michel Achard; Jean-Louis Teboul; Christian Richard; Dominique Perrotin; Guy Ginies
Journal:  Chest       Date:  2002-04       Impact factor: 9.410

Review 7.  Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis.

Authors:  Sachin Sud; Jan O Friedrich; Paolo Taccone; Federico Polli; Neill K J Adhikari; Roberto Latini; Antonio Pesenti; Claude Guérin; Jordi Mancebo; Martha A Q Curley; Rafael Fernandez; Ming-Cheng Chan; Pascal Beuret; Gregor Voggenreiter; Maneesh Sud; Gianni Tognoni; Luciano Gattinoni
Journal:  Intensive Care Med       Date:  2010-02-04       Impact factor: 17.440

8.  Methylene blue used in the treatment of refractory shock resulting from drug poisoning.

Authors:  J Fisher; G Taori; G Braitberg; A Graudins
Journal:  Clin Toxicol (Phila)       Date:  2013-12-24       Impact factor: 4.467

9.  Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock.

Authors:  Angel López; Jose Angel Lorente; Jay Steingrub; Jan Bakker; Angela McLuckie; Sheila Willatts; Michael Brockway; Antonio Anzueto; Laurent Holzapfel; Desmond Breen; Michael S Silverman; Jukka Takala; Jill Donaldson; Carl Arneson; Geraldine Grove; Steven Grossman; Robert Grover
Journal:  Crit Care Med       Date:  2004-01       Impact factor: 7.598

10.  N omega-amino-L-arginine, an inhibitor of nitric oxide synthase, raises vascular resistance but increases mortality rates in awake canines challenged with endotoxin.

Authors:  J P Cobb; C Natanson; W D Hoffman; R F Lodato; S Banks; C A Koev; M A Solomon; R J Elin; J M Hosseini; R L Danner
Journal:  J Exp Med       Date:  1992-10-01       Impact factor: 14.307
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  3 in total

Review 1.  Vasopressor-Sparing Action of Methylene Blue in Severe Sepsis and Shock: A Narrative Review.

Authors:  Filomena Puntillo; Mariateresa Giglio; Alberto Pasqualucci; Nicola Brienza; Antonella Paladini; Giustino Varrassi
Journal:  Adv Ther       Date:  2020-07-23       Impact factor: 3.845

2.  Refractory vasodilatory shock secondary to metformin overdose supported with VA ECMO.

Authors:  Crystal Ives Tallman; Yu Zhang; Nicholas Black; Kara Lynch; Mohamed Fayed; Patil Armenian
Journal:  Toxicol Rep       Date:  2021-12-21

3.  Multiple limb compartment syndrome as a manifestation of capillary leak syndrome secondary to metformin and dipeptidyl peptidase IV inhibitor overdose: A case report.

Authors:  Daisuke Kasugai; Kosuke Tajima; Naruhiro Jingushi; Norimichi Uenishi; Akihiko Hirakawa
Journal:  Medicine (Baltimore)       Date:  2020-07-17       Impact factor: 1.817
  3 in total

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