Literature DB >> 26146551

Redox-Responsive Self-Assembled Chain-Shattering Polymeric Therapeutics.

Kaimin Cai1, Jonathan Yen2, Qian Yin1, Yang Liu1, Ziyuan Song1, Stéphane Lezmi3, Yanfeng Zhang1, Xujuan Yang3, William G Helferich3, Jianjun Cheng4.   

Abstract

We report the design and development of redox-responsive chain-shattering polymeric therapeutics (CSPTs). CSPTs were synthesized by condensation polymerization and further modified with poly(ethylene glycol) (PEG) via "Click" reaction. Size-controlled CSPT nanoparticles (NPs) were formed through nanoprecipitation with high drug loading (up to 18%); the particle size increased in a concentration dependent manner. Drug release from particles was well controlled over 48 h upon redox triggering. The anticancer efficacy of the CSPT NPs was validated both in vitro and in vivo.

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Year:  2015        PMID： 26146551      PMCID： PMC4486357          DOI： 10.1039/C4BM00452C

Source DB:  PubMed          Journal:  Biomater Sci        ISSN： 2047-4830            Impact factor:   6.843


  48 in total

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