Literature DB >> 19294707

Targeting bone metastases with a bispecific anticancer and antiangiogenic polymer-alendronate-taxane conjugate.

Keren Miller1, Rotem Erez, Ehud Segal, Doron Shabat, Ronit Satchi-Fainaro.   

Abstract

A polymer therapeutic designed for combination anticancer and antiangiogenic therapy inhibited the proliferation of prostate carcinoma cells and the proliferation, migration, and tube-formation of endothelial cells. The nanoconjugate was formed from an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer, the bisphosphonate alendronate (for bone targeting), and the chemotherapy agent paclitaxel (PTX), which is cleaved by cathepsin B (see scheme).

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Year:  2009        PMID： 19294707     DOI： 10.1002/anie.200805133

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  41 in total

Review 1.  Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications.

Authors:  Paul Galvin; Damien Thompson; Katie B Ryan; Anna McCarthy; Anne C Moore; Conor S Burke; Maya Dyson; Brian D Maccraith; Yurii K Gun'ko; Michelle T Byrne; Yuri Volkov; Chris Keely; Enda Keehan; Michael Howe; Conor Duffy; Ronan MacLoughlin
Journal:  Cell Mol Life Sci       Date:  2011-10-21       Impact factor: 9.261

Review 2.  Targeting polymer therapeutics to bone.

Authors:  Stewart A Low; Jindřich Kopeček
Journal:  Adv Drug Deliv Rev       Date:  2012-01-28       Impact factor: 15.470

Review 3.  Polymeric materials for theranostic applications.

Authors:  Zhe Wang; Gang Niu; Xiaoyuan Chen
Journal:  Pharm Res       Date:  2013-06-14       Impact factor: 4.200

4.  Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel.

Authors:  Anat Eldar-Boock; Keren Miller; Joaquin Sanchis; Ruth Lupu; María J Vicent; Ronit Satchi-Fainaro
Journal:  Biomaterials       Date:  2011-03-04       Impact factor: 12.479

5.  Chain-shattering polymeric therapeutics with on-demand drug-release capability.

Authors:  Yanfeng Zhang; Qian Yin; Lichen Yin; Liang Ma; Li Tang; Jianjun Cheng
Journal:  Angew Chem Int Ed Engl       Date:  2013-05-06       Impact factor: 15.336

Review 6.  Nanodrug delivery systems: a promising technology for detection, diagnosis, and treatment of cancer.

Authors:  Anish Babu; Amanda K Templeton; Anupama Munshi; Rajagopal Ramesh
Journal:  AAPS PharmSciTech       Date:  2014-02-19       Impact factor: 3.246

Review 7.  Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms.

Authors:  Yuzhe Sun; Edward Davis
Journal:  Nanomaterials (Basel)       Date:  2021-03-16       Impact factor: 5.076

Review 8.  Bone-Targeting Systems to Systemically Deliver Therapeutics to Bone Fractures for Accelerated Healing.

Authors:  Jeffery J Nielsen; Stewart A Low
Journal:  Curr Osteoporos Rep       Date:  2020-10       Impact factor: 5.096

9.  Apatite-binding nanoparticulate agonist of hedgehog signaling for bone repair.

Authors:  Xiao Zhang; Jiabing Fan; Chung-Sung Lee; Soyon Kim; Chen Chen; Tara Aghaloo; Min Lee
Journal:  Adv Funct Mater       Date:  2020-02-05       Impact factor: 18.808

10.  Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis.

Authors:  Salvatore Nicoletti; Karin Seifert; Ian H Gilbert
Journal:  Bioorg Med Chem       Date:  2010-03-02       Impact factor: 3.641
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