Linyong Song1, Qiang Ye2, Xueping Ge1, Paulette Spencer3. 1. University of Kansas, Bioengineering Research Center, 1530 W. 15th Street, Lawrence, KS 66045-7609, USA. 2. University of Kansas, Bioengineering Research Center, 1530 W. 15th Street, Lawrence, KS 66045-7609, USA. Electronic address: yeq@ku.edu. 3. University of Kansas, Bioengineering Research Center, 1530 W. 15th Street, Lawrence, KS 66045-7609, USA; University of Kansas, Department of Mechanical Engineering, 1530 W. 15th Street, Lawrence, KS 66045-7609, USA. Electronic address: pspencer@ku.edu.
Abstract
OBJECTIVES: The objective of this work was to investigate the polymerization behavior, neutralization capability, and mechanical properties of dentin adhesive formulations with the addition of the tertiary amine co-monomer, 2-N-morpholinoethyl methacrylate (MEMA). METHODS: A co-monomer mixture based on HEMA/BisGMA (45/55, w/w) was used as a control adhesive. Compared with the control formulation, the MEMA-containing adhesive formulations were characterized comprehensively with regard to water miscibility of liquid resin, water sorption and solubility of cured polymer, real-time photopolymerization kinetics, dynamic mechanical analysis (DMA), and modulated differential scanning calorimetry (MDSC). The neutralization capacity was characterized by monitoring the pH shift of 1mM lactic acid (LA) solution, in which the adhesive polymers were soaked. RESULTS: With increasing MEMA concentrations, experimental copolymers showed higher water sorption, lower glass transition temperature and lower crosslinking density compared to the control. The pH values of LA solution gradually increased from 3.5 to about 6.0-6.5 after 90 days. With the increase in crosslinking density of the copolymers, the neutralization rate was depressed. The optimal MEMA concentration was between 20 and 40 wt%. CONCLUSIONS: As compared to the control, the results indicated that the MEMA-functionalized copolymer showed neutralization capability. The crosslinking density of the copolymer networks influenced the neutralization rate.
OBJECTIVES: The objective of this work was to investigate the polymerization behavior, neutralization capability, and mechanical properties of dentin adhesive formulations with the addition of the tertiary amine co-monomer, 2-N-morpholinoethyl methacrylate (MEMA). METHODS: A co-monomer mixture based on HEMA/BisGMA (45/55, w/w) was used as a control adhesive. Compared with the control formulation, the MEMA-containing adhesive formulations were characterized comprehensively with regard to water miscibility of liquid resin, water sorption and solubility of cured polymer, real-time photopolymerization kinetics, dynamic mechanical analysis (DMA), and modulated differential scanning calorimetry (MDSC). The neutralization capacity was characterized by monitoring the pH shift of 1mM lactic acid (LA) solution, in which the adhesive polymers were soaked. RESULTS: With increasing MEMA concentrations, experimental copolymers showed higher water sorption, lower glass transition temperature and lower crosslinking density compared to the control. The pH values of LA solution gradually increased from 3.5 to about 6.0-6.5 after 90 days. With the increase in crosslinking density of the copolymers, the neutralization rate was depressed. The optimal MEMA concentration was between 20 and 40 wt%. CONCLUSIONS: As compared to the control, the results indicated that the MEMA-functionalized copolymer showed neutralization capability. The crosslinking density of the copolymer networks influenced the neutralization rate.
Authors: Paulette Spencer; Qiang Ye; Jonggu Park; Elizabeth M Topp; Anil Misra; Orestes Marangos; Yong Wang; Brenda S Bohaty; Viraj Singh; Fabio Sene; John Eslick; Kyle Camarda; J Lawrence Katz Journal: Ann Biomed Eng Date: 2010-02-27 Impact factor: 3.934
Authors: Albert Kingman; Jeffrey Hyman; Scott A Masten; Beby Jayaram; Cynthia Smith; Frederick Eichmiller; Michael C Arnold; Paul A Wong; James M Schaeffer; Sheetal Solanki; William J Dunn Journal: J Am Dent Assoc Date: 2012-12 Impact factor: 3.634
Authors: Linyong Song; Qiang Ye; Xueping Ge; Anil Misra; Jennifer S Laurence; Cynthia L Berrie; Paulette Spencer Journal: J Biomed Mater Res B Appl Biomater Date: 2014-03-05 Impact factor: 3.368