| Literature DB >> 26143992 |
Can Zhang1, Brian S Robinson2, Wenjian Xu3, Liu Yang3, Bing Yao4, Heya Zhao3, Phil K Byun5, Peng Jin4, Alexey Veraksa3, Kenneth H Moberg6.
Abstract
The Hippo pathway is a conserved signaling cascade that modulates tissue growth. Although its core elements are well defined, factors modulating Hippo transcriptional outputs remain elusive. Here we show that components of the steroid-responsive ecdysone (Ec) pathway modulate Hippo transcriptional effects in imaginal disc cells. The Ec receptor coactivator Taiman (Tai) interacts with the Hippo transcriptional coactivator Yorkie (Yki) and promotes expression of canonical Yki-responsive genes. Tai enhances Yki-driven growth, while Tai loss, or a form of Tai unable to bind Yki, suppresses Yki-driven tissue growth. This growth suppression is not correlated with impaired induction of canonical Hippo-responsive genes but with suppression of a distinct pro-growth program of Yki-induced/Tai-dependent genes, including the germline stem cell factors nanos and piwi. These data reveal Hippo/Ec pathway crosstalk in the form a Yki-Tai complex that collaboratively induces germline genes as part of a transcriptional program that is normally repressed in developing somatic epithelia.Entities:
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Year: 2015 PMID： 26143992 PMCID： PMC4519380 DOI： 10.1016/j.devcel.2015.05.010
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270