Etsuyo Tamura1, Yasuhiko Tabata2, Chizumi Yamada3, Shinya Okada4, Masahiro Iida5. 1. a 1 Department of Otorhinolaryngology, Tokai University School of Medicine, Tokai University Tokyo Hospital , Tokyo, Japan. 2. b 2 Institute for Frontier Medical Sciences, Kyoto University , Kyoto, Japan. 3. c 3 Health Screening Center, Tokai University Tokyo Hospital , Tokyo, Japan. 4. d 4 Department of Otorhinolaryngology, Tokai University School of Medicine, Tokai University Hachioji Hospital , Tokyo, Japan. 5. e 5 Department of Otorhinolaryngology, Tokai University School of Medicine , Kanagawa, Japan.
Abstract
CONCLUSION: The volume of fat tissue loss after vocal fold augmentation can be decreased when augmentation is performed with addition of basic fibroblast growth factor (b-FGF). OBJECTIVES: The effectiveness of augmentation is easily decreased due to absorption. Canine experiments have confirmed that the decreased effectiveness caused by absorption after augmentation can be reduced by administering low-concentration b-FGF. Clinical application was trialed after acquiring approval from the institutional clinical review committee. METHOD: Autologous fat tissue with b-FGF was injected into the vocal folds in cases of unilateral vocal cord paralysis. This study compared fat tissue survival after injection by assessing images from computed tomography (CT). RESULTS: Assessments using CT revealed that the decrease in volume of injected fat tissue was smaller in cases treated using b-FGF than in cases using the conventional method. No severe complications were encountered using this method.
CONCLUSION: The volume of fat tissue loss after vocal fold augmentation can be decreased when augmentation is performed with addition of basic fibroblast growth factor (b-FGF). OBJECTIVES: The effectiveness of augmentation is easily decreased due to absorption. Canine experiments have confirmed that the decreased effectiveness caused by absorption after augmentation can be reduced by administering low-concentration b-FGF. Clinical application was trialed after acquiring approval from the institutional clinical review committee. METHOD: Autologous fat tissue with b-FGF was injected into the vocal folds in cases of unilateral vocal cord paralysis. This study compared fat tissue survival after injection by assessing images from computed tomography (CT). RESULTS: Assessments using CT revealed that the decrease in volume of injected fat tissue was smaller in cases treated using b-FGF than in cases using the conventional method. No severe complications were encountered using this method.