Ming Ye1, Jeremy Beach2, Jonathan W Martin3, Ambikaipakan Senthilselvan4. 1. School of Public Health, University of Alberta, Edmonton, AB, Canada. 2. School of Public Health, University of Alberta, Edmonton, AB, Canada; Division of Preventive Medicine, Department of Medicine, University of Alberta, Edmonton, AB, Canada. 3. Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada. 4. School of Public Health, University of Alberta, Edmonton, AB, Canada. Electronic address: sentil@ualberta.ca.
Abstract
OBJECTIVES: Few studies to date have characterized the relationships between diet and urinary concentrations of pesticides. In the current study, associations between dietary factors and urinary concentrations of organophosphate and pyrethroid metabolites were examined in a Canadian general population using data from the Canadian Health Measures Survey (CHMS). METHODS: In the CHMS, urinary concentrations of dialkylphosphate (DAP) and pyrethroid metabolites were measured in 5604 participants aged 6-79 years. Associations between dietary factors and total concentrations of DAP (ΣDAP) and pyrethroid metabolites (ΣPYR) were examined. RESULTS: Over 90% of participants had at least one type of DAP and 99.8% had pyrethroid metabolites detectable in urine samples. After adjusting for age, sex, race/ethnicity, immigrant status and body mass index, ΣDAP among participants with high (3rd tertile) fruit consumption was 1.43 (95% CI: 1.26-1.61) times the concentration among those with low (1st tertile) consumption. ΣDAP was also positively associated with vegetable consumption, for those with high consumption ΣDAP being 1.33 times (95% CI: 1.16-1.52) the concentration for those with low consumption. ΣPYR among participants with high vegetable consumption was 1.42 (95% CI: 1.23-1.66) times the concentration among those with low vegetable consumption. ΣPYR was also positively associated with pulses/nuts consumption (p-values<0.01) and household use of chemicals to control head lice or pet flea (p=0.002). CONCLUSIONS: Positive associations between dietary factors and urinary concentrations of organophosphate and pyrethroid metabolites suggest greater regulation of pesticide use on food products may help to reduce pesticide exposures and associated health risks among the general population.
OBJECTIVES: Few studies to date have characterized the relationships between diet and urinary concentrations of pesticides. In the current study, associations between dietary factors and urinary concentrations of organophosphate and pyrethroid metabolites were examined in a Canadian general population using data from the Canadian Health Measures Survey (CHMS). METHODS: In the CHMS, urinary concentrations of dialkylphosphate (DAP) and pyrethroid metabolites were measured in 5604 participants aged 6-79 years. Associations between dietary factors and total concentrations of DAP (ΣDAP) and pyrethroid metabolites (ΣPYR) were examined. RESULTS: Over 90% of participants had at least one type of DAP and 99.8% had pyrethroid metabolites detectable in urine samples. After adjusting for age, sex, race/ethnicity, immigrant status and body mass index, ΣDAP among participants with high (3rd tertile) fruit consumption was 1.43 (95% CI: 1.26-1.61) times the concentration among those with low (1st tertile) consumption. ΣDAP was also positively associated with vegetable consumption, for those with high consumption ΣDAP being 1.33 times (95% CI: 1.16-1.52) the concentration for those with low consumption. ΣPYR among participants with high vegetable consumption was 1.42 (95% CI: 1.23-1.66) times the concentration among those with low vegetable consumption. ΣPYR was also positively associated with pulses/nuts consumption (p-values<0.01) and household use of chemicals to control head lice or pet flea (p=0.002). CONCLUSIONS: Positive associations between dietary factors and urinary concentrations of organophosphate and pyrethroid metabolites suggest greater regulation of pesticide use on food products may help to reduce pesticide exposures and associated health risks among the general population.
Authors: Axel Mie; Helle Raun Andersen; Stefan Gunnarsson; Johannes Kahl; Emmanuelle Kesse-Guyot; Ewa Rembiałkowska; Gianluca Quaglio; Philippe Grandjean Journal: Environ Health Date: 2017-10-27 Impact factor: 5.984
Authors: Arin A Balalian; Xinhua Liu; Eva Laura Siegel; Julie Beth Herbstman; Virginia Rauh; Ronald Wapner; Pam Factor-Litvak; Robin Whyatt Journal: Int J Environ Res Public Health Date: 2020-08-25 Impact factor: 3.390