Literature DB >> 26136858

Research into europium complexes as magnetic resonance imaging contrast agents (Review).

Guocan Han1, Yangwei Deng2, Jihong Sun1, Jun Ling2, Zhiquan Shen2.   

Abstract

Europium (Eu) is a paramagnetic lanthanide element that possesses an outstanding luminescent property. Eu complexes are ideal fluorescence imaging (FI) agents. Eu2+ has satisfactory relaxivity and optical properties, and can realize magnetic resonance (MRI)-FI dual imaging applications when used with appropriate cryptands that render it oxidatively stable. By contrast, based on the chemical exchange saturation transfer (CEST) mechanism, Eu3+ complexes can provide enhanced MRI sensitivity when used with optimal cryptands, incorporated into polymeric CEST agents or blended with Gd3+. Eu complexes are promising in MRI-FI dual imaging applications and have a bright future.

Entities:  

Keywords:  cryptand; europium; longitudinal relaxivity; magnetic resonance imaging; transverse relaxivity

Year:  2015        PMID： 26136858      PMCID： PMC4471668          DOI： 10.3892/etm.2015.2297

Source DB:  PubMed          Journal:  Exp Ther Med        ISSN： 1792-0981            Impact factor:   2.447


  16 in total

1.  A novel europium(III)-based MRI contrast agent.

Authors:  S Zhang; P Winter; K Wu; A D Sherry
Journal:  J Am Chem Soc       Date:  2001-02-21       Impact factor: 15.419

2.  Oxidatively stable, aqueous europium(II) complexes through steric and electronic manipulation of cryptand coordination chemistry.

Authors:  Nipuni-Dhanesha H Gamage; Yujiang Mei; Joel Garcia; Matthew J Allen
Journal:  Angew Chem Int Ed Engl       Date:  2010-11-15       Impact factor: 15.336

3.  Magnetic Fe3O4 nanoparticles coupled with a fluorescent Eu complex for dual imaging applications.

Authors:  Pinxian Xi; Kai Cheng; Xiaolian Sun; Zhengzhi Zeng; Shouheng Sun
Journal:  Chem Commun (Camb)       Date:  2012-02-07       Impact factor: 6.222

4.  Structural and NMR characterization of Sm(III), Eu(III), and Yb(III) complexes of an amide based polydentate ligand exhibiting paramagnetic chemical exchange saturation transfer abilities.

Authors:  Jason D Dorweiler; Victor N Nemykin; Amanda N Ley; Robert D Pike; Steven M Berry
Journal:  Inorg Chem       Date:  2009-10-05       Impact factor: 5.165

5.  A facile synthesis, in vitro and in vivo MR studies of d-glucuronic acid-coated ultrasmall Ln₂O₃ (Ln = Eu, Gd, Dy, Ho, and Er) nanoparticles as a new potential MRI contrast agent.

Authors:  Krishna Kattel; Ja Young Park; Wenlong Xu; Han Gyeol Kim; Eun Jung Lee; Badrul Alam Bony; Woo Choul Heo; Jae Jun Lee; Seonguk Jin; Jong Su Baeck; Yongmin Chang; Tae Jeong Kim; Ji Eun Bae; Kwon Seok Chae; Gang Ho Lee
Journal:  ACS Appl Mater Interfaces       Date:  2011-09-01       Impact factor: 9.229

6.  Novel Fe3O4@YPO4:Re (Re = Tb, Eu) multifunctional magnetic-fluorescent hybrid spheres for biomedical applications.

Authors:  Wei Wang; Min Zou; Kezheng Chen
Journal:  Chem Commun (Camb)       Date:  2010-06-15       Impact factor: 6.222

7.  Physical Properties of Eu(2+)-Containing Cryptates as Contrast Agents for Ultra-High Field Magnetic Resonance Imaging.

Authors:  Joel Garcia; Akhila N W Kuda-Wedagedara; Matthew J Allen
Journal:  Eur J Inorg Chem       Date:  2012-02-08       Impact factor: 2.524

8.  Synthesis and photophysical properties of an Eu(II)-complex/PS blend: role of Ag nanoparticles in surface-enhanced luminescence.

Authors:  Jong-Moon Kim; Yong-Kwang Jeong; Youngku Sohn; Jun-Gill Kang
Journal:  Langmuir       Date:  2012-06-15       Impact factor: 3.882

9.  Polymeric PARACEST agents for enhancing MRI contrast sensitivity.

Authors:  Yunkou Wu; Youfu Zhou; Olivier Ouari; Mark Woods; Piyu Zhao; Todd C Soesbe; Garry E Kiefer; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2008-09-26       Impact factor: 15.419

10.  Paramagnetic nanoparticle T1 and T2 MRI contrast agents.

Authors:  Wenlong Xu; Krishna Kattel; Ja Young Park; Yongmin Chang; Tae Jeong Kim; Gang Ho Lee
Journal:  Phys Chem Chem Phys       Date:  2012-10-05       Impact factor: 3.676
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  3 in total

1.  Crystallographic Characterization and Non-Innocent Redox Activity of the Glycine Modified DOTA Scaffold and Its Impact on EuIII Electrochemistry.

Authors:  Marianne E Burnett; Bukola Adebesin; S James Ratnakar; Kayla N Green
Journal:  Eur J Inorg Chem       Date:  2018-03-23       Impact factor: 2.524

2.  A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Therapeutic Isotopes.

Authors:  Yaser H Gholami; Lee Josephson; Eman A Akam; Peter Caravan; Moses Q Wilks; Xiang-Zuo Pan; Richard Maschmeyer; Aleksandra Kolnick; Georges El Fakhri; Marc D Normandin; Zdenka Kuncic; Hushan Yuan
Journal:  Int J Nanomedicine       Date:  2020-01-07

Review 3.  Iron Oxide Nanoparticles as T1 Contrast Agents for Magnetic Resonance Imaging: Fundamentals, Challenges, Applications, and Prospectives.

Authors:  Mike Jeon; Mackenzie V Halbert; Zachary R Stephen; Miqin Zhang
Journal:  Adv Mater       Date:  2020-06-04       Impact factor: 32.086
  3 in total

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