Literature DB >> 26136544

Humans In Hypoxia: A Conspiracy Of Maladaptation?!

Jerome A Dempsey1, Barbara J Morgan2.   

Abstract

We address adaptive vs. maladaptive responses to hypoxemia in healthy humans and hypoxic-tolerant species during wakefulness, sleep, and exercise. Types of hypoxemia discussed include short-term and life-long residence at high altitudes, the intermittent hypoxemia attending sleep apnea, or training regimens prescribed for endurance athletes. We propose that hypoxia presents an insult to O2 transport, which is poorly tolerated in most humans because of the physiological cost. ©2015 Int. Union Physiol. Sci./Am. Physiol. Soc.

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Year:  2015        PMID： 26136544      PMCID： PMC4491526          DOI： 10.1152/physiol.00007.2015

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  129 in total

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  28 in total

1.  CrossTalk proposal: Heat acclimatization does improve performance in a cool condition.

Authors:  Christopher T Minson; James D Cotter
Journal:  J Physiol       Date:  2015-12-14       Impact factor: 5.182

2.  Comparison of Sleep Disorders between Real and Simulated 3,450-m Altitude.

Authors:  Raphaël Heinzer; Jonas J Saugy; Thomas Rupp; Nadia Tobback; Raphael Faiss; Nicolas Bourdillon; José Haba Rubio; Grégoire P Millet
Journal:  Sleep       Date:  2016-08-01       Impact factor: 5.849

3.  UBC-Nepal expedition: peripheral fatigue recovers faster in Sherpa than lowlanders at high altitude.

Authors:  Luca Ruggiero; Ryan L Hoiland; Alexander B Hansen; Philip N Ainslie; Chris J McNeil
Journal:  J Physiol       Date:  2018-10-13       Impact factor: 5.182

Review 4.  Intermittent hypoxia training as non-pharmacologic therapy for cardiovascular diseases: Practical analysis on methods and equipment.

Authors:  Tatiana V Serebrovskaya; Lei Xi
Journal:  Exp Biol Med (Maywood)       Date:  2016-07-12

5.  Intermittent hypoxia training in prediabetes patients: Beneficial effects on glucose homeostasis, hypoxia tolerance and gene expression.

Authors:  Tetiana V Serebrovska; Alla G Portnychenko; Tetiana I Drevytska; Vladimir I Portnichenko; Lei Xi; Egor Egorov; Anna V Gavalko; Svitlana Naskalova; Valentina Chizhova; Valeriy B Shatylo
Journal:  Exp Biol Med (Maywood)       Date:  2017-07-31

6.  Physiological Genomics of Adaptation to High-Altitude Hypoxia.

Authors:  Jay F Storz; Zachary A Cheviron
Journal:  Annu Rev Anim Biosci       Date:  2020-11-23       Impact factor: 8.923

Review 7.  High-altitude champions: birds that live and migrate at altitude.

Authors:  Sabine L Laguë
Journal:  J Appl Physiol (1985)       Date:  2017-08-24

8.  Regulation of catecholamine release from the adrenal medulla is altered in deer mice (Peromyscus maniculatus) native to high altitudes.

Authors:  Angela L Scott; Nicole A Pranckevicius; Colin A Nurse; Graham R Scott
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2019-06-26       Impact factor: 3.619

9.  Exercise during Short-Term and Long-Term Continuous Exposure to Hypoxia Exacerbates Sleep-Related Periodic Breathing.

Authors:  Helio Fernandez Tellez; Shawnda A Morrison; Xavier Neyt; Olivier Mairesse; Maria Francesca Piacentini; Eoin Macdonald-Nethercott; Andrej Pangerc; Leja Dolenc-Groselj; Ola Eiken; Nathalie Pattyn; Igor B Mekjavic; Romain Meeusen
Journal:  Sleep       Date:  2016-04-01       Impact factor: 5.849

Review 10.  Phenotypic plasticity, genetic assimilation, and genetic compensation in hypoxia adaptation of high-altitude vertebrates.

Authors:  Jay F Storz; Graham R Scott
Journal:  Comp Biochem Physiol A Mol Integr Physiol       Date:  2020-12-07       Impact factor: 2.320
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