Eman A Bsieso1, Maha Nasr2, Noha H Moftah3, Omaima A Sammour2, Nabaweya A Abd El Gawad1. 1. Department of Pharmaceutics, Faculty of Pharmacy, October 6 University, Giza Governorate, Egypt. 2. Department of Pharmaceutics & Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Monazamet El Wehda El Afrikia St., El Abbassia, Cairo, Egypt. 3. Department of Dermatology, STDs & Andrology, Faculty of Medicine, Al-Minya University, Al-Minya, Egypt.
Abstract
AIM: To study whether the formulation of an antifungal drug in nanovesicular form containing skin penetration enhancer would clinically modulate its therapeutic effectiveness. MATERIALS & METHODS: Nanovesicles containing different skin penetration enhancers 'PEVs' were prepared and loaded with sertaconazole. Penetration-enhancer vesicles were characterized for entrapment efficiency, particle size, zeta potential, elasticity, viscosity, morphology and ex vivo skin deposition. Selected formulae were preliminary tested for clinical efficacy on patients suffering from tinea corporis and tinea versicolor. RESULTS & CONCLUSION: The nanosize of the vesicles, their content of penetration enhancer and their deformable nature are three cornerstones positively influencing the therapeutic outcome of topical antifungal therapy, and hence, can be considered a promising treatment modality for skin fungal diseases.
AIM: To study whether the formulation of an antifungal drug in nanovesicular form containing skin penetration enhancer would clinically modulate its therapeutic effectiveness. MATERIALS & METHODS: Nanovesicles containing different skin penetration enhancers 'PEVs' were prepared and loaded with sertaconazole. Penetration-enhancer vesicles were characterized for entrapment efficiency, particle size, zeta potential, elasticity, viscosity, morphology and ex vivo skin deposition. Selected formulae were preliminary tested for clinical efficacy on patients suffering from tinea corporis and tinea versicolor. RESULTS & CONCLUSION: The nanosize of the vesicles, their content of penetration enhancer and their deformable nature are three cornerstones positively influencing the therapeutic outcome of topical antifungal therapy, and hence, can be considered a promising treatment modality for skin fungal diseases.
Entities:
Keywords:
clinical perspective of efficacy; nanotechnology; penetration-enhancer vesicles; sertaconazole; tinea
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