Vascular endothelial growth factor polymorphisms and lung cancer risk.

The VEGF polymorphisms has been implicated in the susceptibility to lung cancer, but the results are not conclusive. The aim of this study is to investigate the association between the VEGF polymorphisms and the risk of lung cancer by meta-analysis. We searched PubMed, Embase, CNKI and Wanfang databases. A total of 7 case-control studies were included in this meta-analysis. We found that VEGF rs833061 polymorphism showed no significant association with lung cancer risk. Subgroup analysis on race suggested that CC genotype was significantly associated with lung cancer risk in Asian population. We found that VEGF rs699947 polymorphism showed significant association with lung cancer risk. Subgroup analysis on race showed that VEGF rs699947 polymorphism increased lung cancer risk in Asians. In conclusion, this meta-analysis suggested that the VEGF rs699947 is associated with increased risk of lung cancer.