Lauren Daniel1, Anne E Kazak2,3, Yimei Li4,5, Wendy Hobbie4,5, Jill Ginsberg4,5, Eliana Butler4, Lisa Schwartz4,5. 1. Division of Oncology, The Children's Hospital of Philadelphia, 3501 Civic Center Blvd, Philadelphia, PA, 19104, USA. daniell@email.chop.edu. 2. Nemours Children's Health System, 1600 Rockland Road, Wilmington, DE, 19803, USA. 3. Sidney Kimmel Medical School of Thomas Jefferson University, 1025 Walnut St., Philadelphia, PA, 19107, USA. 4. Division of Oncology, The Children's Hospital of Philadelphia, 3501 Civic Center Blvd, Philadelphia, PA, 19104, USA. 5. The Perelman School of Medicine of the University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Abstract
PURPOSE: How cancer history and distress relate to sleep outcomes of adolescents and young adults (AYAs) is unclear. The current study compares AYA cancer survivors to controls on indicators of sleep and fatigue; examines the concurrent association between psychological status, sleep, and fatigue; and investigates the lagged relationship between sleep and fatigue problems with psychological functioning. METHODS: AYA cancer survivors (n = 167) and controls (n = 170), ages 16 to 30, completed measures at a survivorship clinic/primary care visit (time 1) and 2 months later (time 2). Participants completed questions about sleep quality, quantity, sleep medication use, self-reports of sleep problems, and fatigue in addition to measures of depression, anxiety, and posttraumatic stress symptoms (PTSS). RESULTS: There were no differences in sleep quantity or quality between survivors and controls, but survivors reported significantly more fatigue. Within groups, AYAs with self-reported sleep and fatigue problems reported significantly higher depression, anxiety, and PTS symptoms. Controlling for baseline depression, sleep, and fatigue problems at time 1 significantly predicted depression at time 2 in survivors but not in controls. CONCLUSION: This study offers important insight into the psychological functioning of childhood cancer survivors and prospectively describes sleep and fatigue as risk factors for poor psychological functioning in survivors. These findings support screening for sleep problems in AYA survivors as these difficulties are closely related to mental health functioning.
PURPOSE: How cancer history and distress relate to sleep outcomes of adolescents and young adults (AYAs) is unclear. The current study compares AYA cancer survivors to controls on indicators of sleep and fatigue; examines the concurrent association between psychological status, sleep, and fatigue; and investigates the lagged relationship between sleep and fatigue problems with psychological functioning. METHODS: AYA cancer survivors (n = 167) and controls (n = 170), ages 16 to 30, completed measures at a survivorship clinic/primary care visit (time 1) and 2 months later (time 2). Participants completed questions about sleep quality, quantity, sleep medication use, self-reports of sleep problems, and fatigue in addition to measures of depression, anxiety, and posttraumatic stress symptoms (PTSS). RESULTS: There were no differences in sleep quantity or quality between survivors and controls, but survivors reported significantly more fatigue. Within groups, AYAs with self-reported sleep and fatigue problems reported significantly higher depression, anxiety, and PTS symptoms. Controlling for baseline depression, sleep, and fatigue problems at time 1 significantly predicted depression at time 2 in survivors but not in controls. CONCLUSION: This study offers important insight into the psychological functioning of childhood cancer survivors and prospectively describes sleep and fatigue as risk factors for poor psychological functioning in survivors. These findings support screening for sleep problems in AYA survivors as these difficulties are closely related to mental health functioning.
Authors: Justin C Brown; Tania B Huedo-Medina; Linda S Pescatello; Shannon M Pescatello; Rebecca A Ferrer; Blair T Johnson Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-11-04 Impact factor: 4.254
Authors: Ana M Gutierrez-Colina; Grace K Cushman; Cyd K Eaton; Lauren F Quast; Jennifer Lee; Kristin Loiselle Rich; Bonney Reed-Knight; Laura Mee; Rene Romero; Chad Y Mao; Roshan George; Ronald L Blount Journal: Pediatr Transplant Date: 2019-01-03
Authors: Salome Christen; Katharina Roser; Renée L Mulder; Anica Ilic; Hanne C Lie; Jacqueline J Loonen; Anneli V Mellblom; Leontien C M Kremer; Melissa M Hudson; Louis S Constine; Roderick Skinner; Katrin Scheinemann; Jordan Gilleland Marchak; Gisela Michel Journal: J Cancer Surviv Date: 2020-08-25 Impact factor: 4.442