S Baleato-González1, R García-Figueiras2, M I Santiago-Pérez3, I Requejo-Isidro2, J C Vilanova4. 1. Department of Radiology, Hospital Clínico Universitario de Santiago de Compostela, Choupana s/n, 15706 Santiago de Compostela (A Coruña), Spain. Electronic address: baleatorum@hotmail.com. 2. Department of Radiology, Hospital Clínico Universitario de Santiago de Compostela, Choupana s/n, 15706 Santiago de Compostela (A Coruña), Spain. 3. Dirección Xeral de Innovación e Xestión da Saúde Pública, Consellería de Sanidade, SERGAS, San Lazaro s/n, 15703 Santiago de Compostela (A Coruña), Spain. 4. Department of Radiology, Clínica Girona, Institut de Diagnostic per la Imatge, Universitat de Girona, Lorenzana n 36, 17002 Girona, Spain.
Abstract
AIM: To identify and quantify the metabolites detected on proton magnetic resonance spectroscopy ((1)H-MRS) in human testes. MATERIALS AND METHODS: The institutional review board approved the study, and all patients provided informed consent. A total of 27 patients consulting the Urology Department underwent single-voxel (1)H-MRS (4000 ms repetition time [RT], 31 ms echo time [TE], 128 averages for each TE) at 1.5 T. Spectroscopy was not evaluable in one patient, and four patients had only one testis; thus, 48 testes were studied. Choline-containing compounds (Cho) and methylene lipid (Lip) values were measured and the Cho/Lip ratio was calculated. Testes were classified as normal or abnormal based on conventional magnetic resonance imaging (MRI) findings. The Mann-Whitney U-test was used for correlated data and bootstrapping to compare mean Cho/Lip ratios between normal and abnormal testes, and the area under the receiver operating characteristic curve (AUC) was calculated. RESULTS: Thirty testes were classified as normal and 18 as abnormal. The mean Cho/Lip ratio was 1.02±0.46 in normal testes and 0.45±0.36 in abnormal testes (Mann-Whitney U, p=0.001; bootstrapping mean difference, 0.57; 95% confidence interval (CI) 0.32-0.82; AUC=0.833). CONCLUSION: (1)H-MRS could be useful in routine clinical practice to identify the major metabolites in the testes and help discriminate between normal and abnormal testes.
AIM: To identify and quantify the metabolites detected on proton magnetic resonance spectroscopy ((1)H-MRS) in human testes. MATERIALS AND METHODS: The institutional review board approved the study, and all patients provided informed consent. A total of 27 patients consulting the Urology Department underwent single-voxel (1)H-MRS (4000 ms repetition time [RT], 31 ms echo time [TE], 128 averages for each TE) at 1.5 T. Spectroscopy was not evaluable in one patient, and four patients had only one testis; thus, 48 testes were studied. Choline-containing compounds (Cho) and methylene lipid (Lip) values were measured and the Cho/Lip ratio was calculated. Testes were classified as normal or abnormal based on conventional magnetic resonance imaging (MRI) findings. The Mann-Whitney U-test was used for correlated data and bootstrapping to compare mean Cho/Lip ratios between normal and abnormal testes, and the area under the receiver operating characteristic curve (AUC) was calculated. RESULTS: Thirty testes were classified as normal and 18 as abnormal. The mean Cho/Lip ratio was 1.02±0.46 in normal testes and 0.45±0.36 in abnormal testes (Mann-Whitney U, p=0.001; bootstrapping mean difference, 0.57; 95% confidence interval (CI) 0.32-0.82; AUC=0.833). CONCLUSION: (1)H-MRS could be useful in routine clinical practice to identify the major metabolites in the testes and help discriminate between normal and abnormal testes.
Authors: Alexandra Ntorkou; Athina C Tsili; Loukas Astrakas; Anna Goussia; Eleni Panopoulou; Nikolaos Sofikitis; Maria I Argyropoulou Journal: Eur Radiol Date: 2020-03-30 Impact factor: 5.315
Authors: Athina C Tsili; Nikolaos Sofikitis; Ourania Pappa; Christina K Bougia; Maria I Argyropoulou Journal: Cancers (Basel) Date: 2022-08-13 Impact factor: 6.575