Literature DB >> 26126425

Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs).

Susan Sammak1, Giovanna Zinzalla2.   

Abstract

In this review we discuss recent progress in targeting the protein-protein interactions made by oncogenic transcription factors. We particularly focus on the challenges posed by the prevalence of intrinsically disordered regions in this class of protein and the strategies being used to overcome them.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Anticancer therapy; HIF-1; Intrinsically disordered proteins; Protein–protein interactions; STAT3; Transcription factors; c-MYC; β-catenin

Mesh：

Substances：

Year:  2015        PMID： 26126425     DOI： 10.1016/j.pbiomolbio.2015.06.004

Source DB:  PubMed          Journal:  Prog Biophys Mol Biol        ISSN： 0079-6107            Impact factor:   3.667


  12 in total

Review 1.  Balanced between order and disorder: a new phase in transcription elongation control and beyond.

Authors:  Huasong Lu; Rongdiao Liu; Qiang Zhou
Journal:  Transcription       Date:  2019-01-31

2.  TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling.

Authors:  Ewelina Guca; David Suñol; Lidia Ruiz; Agnieszka Konkol; Jorge Cordero; Carles Torner; Eric Aragon; Pau Martin-Malpartida; Antoni Riera; Maria J Macias
Journal:  Nucleic Acids Res       Date:  2018-09-28       Impact factor: 16.971

3.  Role of Backbone Dynamics in Modulating the Interactions of Disordered Ligands with the TAZ1 Domain of the CREB-Binding Protein.

Authors:  Rebecca B Berlow; Maria A Martinez-Yamout; H Jane Dyson; Peter E Wright
Journal:  Biochemistry       Date:  2019-02-22       Impact factor: 3.162

Review 4.  Regulation of fibroblast-like synoviocyte transformation by transcription factors in arthritic diseases.

Authors:  Pallavi Bhattaram; Kyle Jones
Journal:  Biochem Pharmacol       Date:  2019-03-13       Impact factor: 5.858

Review 5.  Targeted protein degradation: A promise for undruggable proteins.

Authors:  Kusal T G Samarasinghe; Craig M Crews
Journal:  Cell Chem Biol       Date:  2021-05-17       Impact factor: 9.039

Review 6.  Therapeutic Interventions of Cancers Using Intrinsically Disordered Proteins as Drug Targets: c-Myc as Model System.

Authors:  Deepak Kumar; Nitin Sharma; Rajanish Giri
Journal:  Cancer Inform       Date:  2017-03-16

7.  Bioinformatics analysis of the proteins interacting with LASP-1 and their association with HBV-related hepatocellular carcinoma.

Authors:  Fan-Yun Kong; Ting Zhu; Nan Li; Yun-Fei Cai; Kai Zhou; Xiao Wei; Yan-Bo Kou; Hong-Juan You; Kui-Yang Zheng; Ren-Xian Tang
Journal:  Sci Rep       Date:  2017-03-07       Impact factor: 4.379

Review 8.  Targeting Intrinsically Disordered Proteins through Dynamic Interactions.

Authors:  Jianlin Chen; Xiaorong Liu; Jianhan Chen
Journal:  Biomolecules       Date:  2020-05-11

9.  Rational design using sequence information only produces a peptide that binds to the intrinsically disordered region of p53.

Authors:  Kiyoto Kamagata; Eriko Mano; Yuji Itoh; Takuro Wakamoto; Ryo Kitahara; Saori Kanbayashi; Hiroto Takahashi; Agato Murata; Tomoshi Kameda
Journal:  Sci Rep       Date:  2019-06-28       Impact factor: 4.379

10.  Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.

Authors:  Mareike M Wiedmann; Yaw Sing Tan; Yuteng Wu; Shintaro Aibara; Wenshu Xu; Hannah F Sore; Chandra S Verma; Laura Itzhaki; Murray Stewart; James D Brenton; David R Spring
Journal:  Angew Chem Int Ed Engl       Date:  2016-12-05       Impact factor: 16.823
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