Hung-Jen Chen1, Wen-Shin Chang2, Te-Chun Hsia1, Chia-En Miao3, Wei-Chun Chen4, Shinn-Jye Liang4, An-Chyi Chen3, Jan-Gowth Chang3, Chia-Wen Tsai3, Chin-Mu Hsu3, Chang-Hai Tsai3, Da-Tian Bau5. 1. Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. Department of Respiratory Therapy, China Medical University, Taichung, Taiwan, R.O.C. 2. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C. 3. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. 4. Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. 5. Terry Fox Cancer Research Laboratory, China Medical University Hospital, Taichung, Taiwan, R.O.C. Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C. Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C. artbau2@gmail.com datian@mail.cmuh.org.tw.
Abstract
AIM: The present study evaluated the contribution of genotype of X-ray repair cross-complementing group 3 (XRCC3), age, gender, and smoking to lung cancer risk in Taiwan. MATERIALS AND METHODS: A total of 358 patients with lung cancer and 716 controls were investigated for their XRCC3 rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539, rs28903081 genotype, epidemiological and clinical data for association and gene-Iifestyle interactions. RESULTS: The results showed that CT and TT genotypes of XRCC3 rs861539 were associated with increased lung cancer risk (odds ratio=1.81, 95% confidence interval=1.18-2.78; odds ratio=3.43, 95% confidence interval=1.12-10.60, respectively). This polymorphism also influenced lung cancer susceptibility in males and smokers (p=0.0017 and 0.0045, respectively). CONCLUSION: The T allele of XRCC3 rs861539 contributes to increased risk of lung cancer in Taiwanese, particularly those who are male and smokers. Copyright
AIM: The present study evaluated the contribution of genotype of X-ray repair cross-complementing group 3 (XRCC3), age, gender, and smoking to lung cancer risk in Taiwan. MATERIALS AND METHODS: A total of 358 patients with lung cancer and 716 controls were investigated for their XRCC3rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539, rs28903081 genotype, epidemiological and clinical data for association and gene-Iifestyle interactions. RESULTS: The results showed that CT and TT genotypes of XRCC3rs861539 were associated with increased lung cancer risk (odds ratio=1.81, 95% confidence interval=1.18-2.78; odds ratio=3.43, 95% confidence interval=1.12-10.60, respectively). This polymorphism also influenced lung cancer susceptibility in males and smokers (p=0.0017 and 0.0045, respectively). CONCLUSION: The T allele of XRCC3rs861539 contributes to increased risk of lung cancer in Taiwanese, particularly those who are male and smokers. Copyright
Authors: Albert Rosenberger; Rayjean J Hung; David C Christiani; Neil E Caporaso; Geoffrey Liu; Stig E Bojesen; Loic Le Marchand; Ch A Haiman; Demetrios Albanes; Melinda C Aldrich; Adonina Tardon; G Fernández-Tardón; Gad Rennert; John K Field; B Kiemeney; Philip Lazarus; Aage Haugen; Shanbeh Zienolddiny; Stephen Lam; Matthew B Schabath; Angeline S Andrew; Hans Brunnsstöm; Gary E Goodman; Jennifer A Doherty; Chu Chen; M Dawn Teare; H-Erich Wichmann; Judith Manz; Angela Risch; Thomas R Muley; Mikael Johansson; Paul Brennan; Maria Teresa Landi; Christopher I Amos; Beate Pesch; Georg Johnen; Thomas Brüning; Heike Bickeböller; Maria Gomolka Journal: Int Arch Occup Environ Health Date: 2018-07-03 Impact factor: 3.015
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