| Literature DB >> 26122562 |
Bin Zhang1,2, Wei Xia1, Yuanyuan Li1, Bryan A Bassig3, Aifen Zhou2, Youjie Wang1, Zhengkuan Li4, Yuanxiang Yao5, Jie Hu1, Xiaofu Du1, Yanqiu Zhou1, Juan Liu1, Weiyan Xue1, Yue Ma1, Xinyun Pan1, Yang Peng1, Tongzhang Zheng3, Shunqing Xu1.
Abstract
We investigated the association between prenatal exposure to lead (Pb) and the risk of preterm low birth weight (PLBW). Pb concentrations in maternal urine collected at birth from 408 subjects (102 cases and 306 matched controls) were analyzed and adjusted by creatinine. The median Pb concentration in the PLBW cases (10.60μgPb/g creatinine) was higher than that of the controls (7.28μgPb/g creatinine). An adjusted odds ratio (OR) of 2.96 (95% CI=1.49-5.87) for PLBW was observed when the highest tertile was compared to the lowest tertile of Pb levels. The association was more pronounced among female infants (adjusted OR=3.67 for the highest tertile; 95% CI=1.35-9.93) than male infants (adjusted OR=1.91 for the highest tertile; 95% CI=0.74-4.95). Our study suggests that prenatal exposure to levels of Pb encountered today in China is associated with an elevated risk of PLBW.Entities:
Keywords: Lead; Maternal urine; Prenatal exposure; Preterm birth
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Year: 2015 PMID： 26122562 PMCID： PMC4843791 DOI： 10.1016/j.reprotox.2015.06.051
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143